G2 phase, Gap 2 phase, or Growth 2 phase, is the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated. G 2 phase ends with the onset of prophase, the first phase of mitosis in which the cell’s chromatin condenses into chromosomes.

2019年3月18日 · The G2 phase of cell division comes after the DNA synthesis S phase and before the mitosis M phase. G2 is the gap between DNA replication and cell splitting and is used to assess the cell's readiness for mitosis. A key verification process is checking the …

2024年10月24日 · 细胞周期（Cell Cycle）是指连续分裂的细胞从一次分裂完成时开始，到下一次分裂完成时为止所经历的全过程。 它主要包括两个阶段：分裂间期和分裂期。

G2/M transition (or mitotic entry) is the progression from G2-phase to M-phase (also referred to as “mitosis”) of the mitotic cell division cycle. Eukaryotic cells govern a repetitive series of events that result in self-reproduction (Morgan 2006).

Cells synthesize proteins and prepare for DNA replication occurring in S phase. During G2 phase, cells enhance the de novo lipid synthesis required for membrane formation and ensure that everything is ready to initiate the mitotic process. Martin Fischer, ... James A. DeCaprio, in Hematology (Seventh Edition), 2018.

The G2 phase of the cell cycle is when the cell finishes preparing for division. The last part of interphase is called the G2 phase. The cell has grown, DNA has been replicated, and now the cell is almost ready to divide. This last stage is all about prepping the cell for mitosis or meiosis.

2024年7月8日 · We find that G2 cells with oncogenic ERK signaling can persistently inhibit CDKs and prematurely re-activate the APC/C without mitotic entry. This G2 cell cycle exit event results in tetraploid cells that resemble a G0/G1 biochemical state and are thus poised for WGD via endoreplication of the genome.

In this review, we present major pathways that govern genome integrity in the G2 phase of the cell cycle. We highlight the strong interplay between the control of the unperturbed cell cycle transition, and the DNA damage signaling initiated by various DNA damage structures.

We show here that DNA damage, including DNA damage associated with inflammation-induced replication stress, and attendant G2 arrest that facilitates hyperploidization, are a major driver of rapid MK priming and differentiation from HSCs.

4 天之前 · Role in Cell Cycle Progression. The G2 checkpoint acts as a regulatory barrier between DNA replication and mitosis, ensuring cells do not proceed with errors that could compromise genomic stability. Positioned at the G2-to-mitosis transition, it assesses whether DNA replication has been completed accurately. If errors are detected, the ...