Polyclonal Antibody for studying G3BP-1. Validated for IF, WB. Highly specific and rigorously validated in-house, G3BP1 Antibody (CST #17798) is ready to ship.

2012年6月4日 · 13057-2-AP targets G3BP1 in WB, IHC, IF/ICC, FC (Intra), IP, CoIP, RIP, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

2020年4月17日 · Jude Children’s Research Hospital的 J. Paul Taylor 组，题目为 G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules。 杨培国 博士等人首次在全基因组范围内筛选出了调控SG形成的重要蛋白组分，系统的研究了参与SG形成的蛋白网络以及重要组分在其形成中的作用。 该研究发现 SG的形成起始于一个包括G3BP1蛋白在内的核心SG网络，该网络由蛋白-蛋白、蛋白-RNA、RNA-RNA相互作用交织而成。 当相互协同作 …

Rabbit monoclonal [EPR13986(B)] to G3BP; Suitable for: WB, ICC/IF, IP, Flow Cyt (Intra), IHC-P; Knockout validated; Reacts with: Mouse, Rat, Human

2024年1月31日 · G3BP1 is an RNA binding protein that condenses untranslating messenger RNAs into stress granules (SGs). G3BP1 is inactivated by multiple viruses and is thought to antagonize viral replication by SG-enhanced antiviral signaling. Here, we show that neither G3BP1 nor SGs generally alter the activation of innate immune pathways.

G3BP 是一种位点特异性核糖核酸内切酶，在正常细胞中普遍表达。 G3BP1 在肺和肾中高度表达，而 G3BP2 主要存在于小肠和脑中。 G3BP作为Ras信号通路的重要下游效应子，可能以Ras-GAP依赖的方式影响RNA代谢。 G3BP1还通过促进视黄酸诱导基因I（RIG-I）识别RNA病毒，发挥抗病毒作用。 此外，G3BP调节mRNA的翻译和衰减，从而影响基因表达，并与多种疾病有关，包括癌症、胚胎致死、动脉硬化和神经发育障碍。 1. 贴壁细胞：取洁净无菌盖玻片置于培 …

Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Western blot analysis of G3BP expression in Hela cell lysate. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.