2024年12月25日 · G3BP1 (G3BP Stress Granule Assembly Factor 1) is a Protein Coding gene. Diseases associated with G3BP1 include Glioma Susceptibility 1 and Chikungunya. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA binding.

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. [5] [6] [7] This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.

2020年4月17日 · Jude Children’s Research Hospital的J. Paul Taylor组，题目为G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules。 杨培国 博士等人首次在全基因组范围内筛选出了调控SG形成的重要蛋白组分，系统的研究了参与SG形成的蛋白网络以及重要组分在其形成中的作用。

根据这项研究，目前已知 G3BP 将结节性硬化复合体 (TSC) 与溶酶体连接在一起，并通过分子组雷帕霉素靶蛋白复合体 1 (mTORC1) 来抑制信号转导。 这一发现的意义重大，因为 mTORC1 过度活化与典型特征为细胞过度生长、迁移和神经元兴奋性的疾病有关。 因此 G3BP 可能是癌症和神经元疾病的重要治疗靶标。 所有 CST 抗体均根据 Hallmarks of Antibody Validation™ 进行了严格验证，因此研究人员能够高效地获得明确的结果。 这包括对 G3BP 与 TSC 复合体之间的物理相 …

Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is a multi-functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism.

2020年4月16日 · The central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations. Moreover, we show that interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulates its intrinsic propensity for LLPS, and this is fine ...

2020年4月16日 · Biophysical studies revealed details of how G3BP1 functions as a molecular switch that triggers RNA-dependent LLPS. Importantly, interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulates its intrinsic propensity for LLPS, and this is fine-tuned by phosphorylation within the IDRs.

2018年12月3日 · Here we report that GTPase-activating protein SH3 domain–binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. G3BP1 enhanced DNA binding of cGAS by promoting...

2022年5月5日 · Ras-GTPase-activating protein binding protein 1 (G3BP1) is a multifunctional binding protein involved in a variety of biological functions, including cell proliferation, metastasis, apoptosis, differentiation and RNA metabolism.

该基因编码一种 DNA 解旋酶，它更倾向于部分解旋的 3' 尾底物，也可以以 ATP 依赖性方式解旋部分 RNA/DNA 和 RNA/RNA 双链体。 这种酶是异质核 RNA 结合蛋白的成员，也是 Ras 信号转导通路的一个组成部分。 它通过与其 SH3 结构域相关联而特异性结合 Ras-GTPase 激活蛋白。 已经描述了该基因的几种可变剪接的转录本变体，但尚未确定其中一些变体的全长性质。 [RefSeq 提供，2008 年 7 月]