In this review, we will challenge this model depicting G4s as simple ‘off switches’ for gene expression by articulating how their formation has the potential to alter gene expression at many different levels, acting as a key regulatory element perturbing the nature of epigenetic marks and chromatin architecture. Graphical Abstract.

2022年2月27日 · G‐quadruplexes (G4s) are a class of non‐canonical nucleic acid secondary structures. Four guanine bases self‐associate via Hoogsteen hydrogen bonds into a square planar conformation, namely, G‐quartet (Figure 1A). Two or three layers of G‐quartets stack into peculiar structural motifs, which are called G4s (Figure 1B).

G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill important genome regulatory functions.

2020年11月24日 · G4s are highly polymorphic intra- or intermolecular structures whose topology can be influenced by variations in strand stoichiometry and polarity, as well as by the nature and length of loops and their location in the sequence .

G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures formed by guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the biological roles of G4s in microbial genomes with emphasis on recent ...

2022年12月12日 · G-quadruplexes (G4s) are four-stranded DNA secondary structures that occur in the human genome and play key roles in transcription, replication, and genome stability. G4-specific molecular probes are of vital importance to elucidate the structure and function of G4s.

G-quadruplexes (G4s) are guanine-rich, four-stranded nucleic acid structures that are abundantly found in the promoter region of various oncogenes (cMYC, cKIT, KRAS, etc.) and in the telomeric region. The ligand-induced stabilization of G4s is shown to be efficient in targeted cancer therapy, and simultaneously targeting multiple G4s is beneficial.

2023年12月1日 · G-quadruplexes (G4s) are secondary structures in DNA and RNA that impact various cellular processes, such as transcription, splicing, and translation. Due to their numerous functions, G4s are involved in many diseases, making their study important.

G4S [11] [12] London: Rubicon International Services: London: Ex commonwealth SF. Acquired by Aegis Defence Services on 28 October 2005. International Intelligence Limited: Eastington, Stroud: Specialist contracts. Operates in the security and intelligence sectors. Sandline International: London: Ceased operations on April 16, 2004

2025年3月28日 · The two largest Chinese PSCs in Africa, G4S and Control Risks, are Chinese branches of UK-owned companies. [3] The Hong Kong-based PSC, Frontier Services Group (先丰服务集团), was founded by Erik Prince, the Former Head of the United States-based PMC Blackwater Worldwide. [3]