G6b-B regulates an essential step in megakaryocyte maturation
G6b-B–deficient mice display reduced levels of MK-specific transcripts, surface receptors, GATA-1, and thrombopoietin signaling. G6b-B is a megakaryocyte lineage-specific immunoreceptor …
G6b-B regulates an essential step in megakaryocyte maturation
2022年5月24日 · G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif-containing receptor, essential for platelet homeostasis. Mice with a genomic …
对红细胞生成至关重要的 GATA-1 调节的 microRNA 簇。,Blood
2007年11月16日 · 核因子 gata-1 通过调节众多蛋白质编码基因的转录来控制红细胞生成。 在这里，我们表明 GATA-1 还激活了一个关键的红细胞微 RNA (miR) 基因座的表达。 MicroRNA 通 …
Figure 1. Gata1 low mice respond to treatment with growth …
We here identified macrothrombocytopenic mice with a mutation within Mpig6b encoding the ITIM-bearing receptor G6b-B. G6b-B-mutant mice developed a severe myelofibrosis associated …
Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε …
2002年11月8日 · Our findings identify novel combinatorial protein-protein interactions for GATA-1, PU.1, and C/EBPε isoforms in eosinophil gene transcription that include GATA-1/PU.1 synergy …
G6b-B regulates an essential step in megakaryocyte maturation
G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the …
Mechanism of KIT gene regulation by GATA1 lacking the N
2022年11月29日 · GATA1 is a transcription factor expressed in erythrocytes, megakaryocytes, eosinophils and mast cells. GATA1 has an N-terminal transcription activation domain (NTD) …
G6b-B regulates an essential step in megakaryocyte maturation
2022年5月24日 · G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing receptor, essential for platelet homeostasis. Mice with a genomic …
GATA1 controls numbers of hematopoietic progenitors and their …
2022年12月13日 · GATA1 regulates numbers of HSPCs in the BM, and the ΔdblGATA mutation causes a functional deficit during inflammation. GATA-binding factor 1 (GATA1) is a …
A pathobiologic pathway linking TPO, GATA-1, and TGF-  1 in …
Moreover, G6b-B was shown to be indispensable for MK maturation as verified by a significant reduction in MK-specific gene expression in G6b-B-mutant MKs due to reduced GATA-1 activity.