Structural insights into glucose-6-phosphate recognition and
2025年1月23日 · Here, we present two cryo-EM structures of the 40-kDa human G6Pase: a wild-type apo form and a mutant G6Pase-H176A with G6P bound, elucidating the structural basis …
Structural insights into glucose-6-phosphate recognition and …
2025年1月23日 · The glucose-6-phosphatase (G6Pase) is an integral membrane protein that catalyzes the hydrolysis of glucose-6-phosphate (G6P) in the endoplasmic reticulum lumen …
Dual Mechanisms for Glucose 6-Phosphate Inhibition of Human …
1999年10月29日 · Brain hexokinase (HKI) is inhibited potently by its product glucose 6-phosphate (G6P); however, the mechanism of inhibition is unsettled. Two hypotheses have been …
2024年3月12日 · We investigated a glycolytic enzymatic reaction, the conversion of glucose-6-phosphate to 6-phospho-D-glucono-1,5-lactone with concomitant reduction of NADP+ to …
The role of glucose-6-phosphatase activity in glucose homeostasis …
2024年10月18日 · Glycemic control is dependent on the activity of hepatic glucose-6-phosphatase catalytic subunit (G6PC)1 and pancreatic beta cell G6PC2 that both catalyze the …
Glucose-6-phosphatase Catalytic Subunit Gene Family
2009年10月10日 · Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate. It is a multicomponent system located in the …
The glucose-6-phosphate transport is not mediated by a glucose …
2012年9月21日 · A phosphate-linked antiporter activity of the glucose-6-phosphate transporter (G6PT) has been recently described in liposomes including the reconstituded transporter …
Enabling High Activation of Glucose‐6‐Phosphate ... - Chemistry …
2024年3月12日 · This study focuses on the enzymatic reaction of glucose-6-phosphate (G6P) and the cofactor NADP + by glucose-6-phosphate dehydrogenase (G6PDH), leading to 6-phospho …
Biophysical and functional properties of purified glucose-6 …
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) plays a critical role in hepatic glucose production during fasting by mediating the terminal step of the gluconeogenesis and …
Structural and biochemical evidence of the glucose 6-phosphate ...
2020年6月12日 · Activation of phosphoenolpyruvate carboxylase (PEPC) enzymes by glucose 6-phosphate (G6P) and other phospho-sugars is of major physiological relevance. Previous …