Glucose 6-phosphatase - Wikipedia
Glucose 6-phosphatase consists of 357 amino acids, and is anchored to the endoplasmic reticulum (ER) by nine transmembrane helices. Its N-terminal and active site are found on the …
G6Pase location in the endoplasmic reticulum: Implications on ...
2019年2月26日 · The main features of FDG kinetics resulting from the introduction of the ER pool may be summarized in two points: (1) ER significantly contributes to G6P metabolism, and (2) …
The glucose-6-phosphate transport is not mediated by a glucose …
2012年9月21日 · G6PT mediates the influx of glucose-6-phosphate (G6P) into the endoplasmic reticulum. A Pi-linked antiporter activity of G6PT has been previously described in liposomes. …
The role of glucose-6-phosphatase activity in glucose homeostasis …
2024年10月18日 · G6PC1 and G6PC2 are integral membrane proteins embedded in the endoplasmic reticulum (ER). Understanding their structural features paves the way for …
Structural insights into glucose-6-phosphate recognition and …
2025年1月23日 · Here, we present two cryo-EM structures of the 40-kDa human G6Pase: a wild-type apo form and a mutant G6Pase-H176A with G6P bound, elucidating the structural basis …
Glucose-6-phosphatase Catalytic Subunit Gene Family - PMC
Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate. It is a multicomponent system located in the endoplasmic reticulum that …
Effective Glucose Uptake by Human Astrocytes Requires Its …
After its uptake into the cytosol, intracellular glucose is phosphorylated to glucose-6-phosphate (G6P), trapping it within the cell and preparing it for metabolism. In glucose-exporting tissues, …
Mutations in the Glucose-6-Phosphatase-α (G6PC) Gene that …
Mutations in the G6PC gene, located on chromosome 17q21, result in glycogen storage disease type Ia (GSD-Ia), an autosomal recessive metabolic disorder. GSD-Ia patients manifest a …
Transmembrane Topology of Human Glucose 6-Phosphate …
Our data suggest that both G6PT-5′fXaFLAG and G6PT-3′fXaFLAG constructs were anchored in the ER membrane and functioned as a G6P transporter. Intact microsomes, isolated from …
Molecular biology and gene therapy for glycogen storage
The primary function of G6PT is to translocate G6P from the cytoplasm into the lumen of the endoplasmic reticulum (ER). Inside the ER, G6P is hydrolyzed to glucose and phosphate by …
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