G6PD gene contributes to the production of glucose-6-phosphate dehydrogenase. Chemical reactions involving glucose-6-phosphate dehydrogenase produce compounds that prevent reactive oxygen species from building up to toxic levels within red blood cells.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic defect common in people with African ancestry that can result in hemolysis after acute illnesses or intake of oxidant medications or substances (including salicylates and sulfonamides).

2020年9月10日 · Glucose 6-phosphate dehydrogenase (G6PD) deficiency is 1 of the commonest human enzymopathies, caused by inherited mutations of the X-linked gene G6PD. G6PD deficiency makes red cells highly vulnerable to oxidative damage, and therefore susceptible to …

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human enzyme deficiencies in the world. It is particularly common in populations living in...

2022年9月26日 · G6PD is the catalyst in the rate-limiting first step of the pentose phosphate pathway, which uses glucose-6-phosphate to convert nicotinamide adenine dinucleotide phosphate (NADP) into its reduced form, NADPH.

Blood film features: Bite cells Blister cells Irregularly-contracted cells Spherocytes Polychromasia Investigations: Heinz body test Glucose-6-phosphade dehydrogenase (G6PD) quantification Differential diagnosis G6PD deficiency Drugs (e.g. dapsone, Bactrim, sulphasalazine) Unstable haemoglobins Other resources: ASH Image Bank: Oxidative Hemolysis

2024年4月12日 · The blood film was strongly suggestive of severe oxidant-induced hemolytic anemia, raising the possibility of G6PD deficiency. An assay showed low G6PD activity of 2.4 u/gHb (normal range 6.3–11.2 u/gHb).

2025年1月18日 · The Glucose-6-phosphate Dehydrogenase (G6PD) Test measures the activity of the G6PD enzyme in red blood cells. Moreover, G6PD plays a crucial role in protecting red blood cells from oxidative damage. In addition, this test helps diagnose G6PD deficiency, a genetic disorder affecting enzyme production.

The role of blood film analysis in the diagnosis of G6PD deficiency will be the main focus of section six. By analyzing red blood cells under a microscope, healthcare professionals can gain valuable insights that help differentiate G6PD deficiency from other forms of anemia, leading to appropriate management and treatment strategies.

2024年8月6日 · The enzyme glucose-6-phosphate dehydrogenase (G6PD) is one of the enzymes of the pentose phosphate pathway. This pathway is involved in keeping an adequate amount of the coenzyme nicotinamide adenine dinucleotide phosphate (NADPH) in cells. NADPH in turn maintains the levels of glutathione which protects the red cell from oxidative damage.