2024年12月25日 · G6PC1 (Glucose-6-Phosphatase Catalytic Subunit 1) is a Protein Coding gene. Diseases associated with G6PC1 include Glycogen Storage Disease Ia and Hypoglycemia. Among its related pathways are Gene expression (Transcription) and Gluconeogenesis. An important paralog of this gene is G6PC2.

Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population. G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity. G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo.

葡萄糖 6 磷酸酶 (G6Pase) 是内质网的多亚基整合膜蛋白，由催化亚基和 G6P、无机磷酸盐和葡萄糖的转运蛋白组成。 该基因 (G6PC) 是人类三种葡萄糖-6-磷酸酶催化亚基编码基因之一：G6PC、G6PC2 和 G6PC3。 6-磷酸葡萄糖酶催化 D-葡萄糖 6-磷酸水解为 D-葡萄糖和正磷酸盐，是葡萄糖体内平衡的关键酶，在糖异生和糖原分解中发挥作用。 该基因的突变会导致 I 型糖原贮积病 (GSD1) 。 这种疾病也称为 von Gierke 病，是一种代谢紊乱，其特征是严重的低血糖症与肝脏 …

2025年2月8日 · Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I …

2025年1月23日 · In conjunction with functional analyses, this study provides critical insights into the structure, substrate recognition, catalytic mechanism, and pathology of G6Pase. Keywords: G6P hydrolysis; G6PC1; G6Pase; GSD-1a; cryo-EM structure.

2025年1月4日 · Gene target information for G6PC1 - glucose-6-phosphatase catalytic subunit 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

HGNC Approved Gene Symbol: G6PC1. Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38) : 17:42,900,799-42,914,438 (from NCBI) Glucose-6-phosphatase (G6PC; EC …

Enables glucose-6-phosphatase activity. Involved in several processes, including gluconeogenesis; phosphorylated carbohydrate dephosphorylation; and response to resveratrol. Located in intracellular membrane-bounded organelle. Used to study type 2 diabetes mellitus. Biomarker of fatty liver disease.

葡萄糖-6-磷酸酶（G6Pase）是一种内质网的多亚基整合膜蛋白，由一个催化亚单位和G6P、无机磷酸盐和葡萄糖的转运子组成。 这个基因（G6PC）是人类三种葡萄糖-6-磷酸酶催化亚基编码基因之一：G6PC、G6PC2和G6PC3。 葡萄糖-6-磷酸酶催化D-葡萄糖-6-磷酸的水解为D-葡萄糖和正磷酸盐，是葡萄糖体内平衡的关键酶，在糖异生和糖原分解中发挥作用。 这个基因的突变导致I型糖原储存病（GSD1）。 这种疾病，也称为von Gierke病，是一种代谢紊乱，其特点是严重的低 …

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). [6]