Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene. [5][6][7] This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family.

2024年12月25日 · G6PC2 (Glucose-6-Phosphatase Catalytic Subunit 2) is a Protein Coding gene. Diseases associated with G6PC2 include Glycogen Storage Disease Ia and Basophilic Adenocarcinoma.

2025年2月8日 · Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach. G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo.

Glucose-6-phosphatase catalytic subunit (G6PC)1 and G6PC2 are crucial for glucose metabolism, regulating processes like glycolysis, gluconeogenesis, and glycogenolysis. Despite their structural and functional similarities, G6PC1 and G6PC2 exhibit distinct tissue-specific expression patterns, G6P hydrolysis kinetics, and physiological functions.

2025年1月1日 · The catalytic subunit of the islet-specific glucose-6-phosphatase enzyme (G6PC2) opposes the action of glucokinase and creates a futile substrate cycle (12 – 14). Multiple genome-wide association studies (GWASs) have linked polymorphisms in G6PC2 with variations in fasting blood glucose and HbA1c with high statistical significance (15 – 18).

由该基因编码的家族成员存在于胰岛中，不表现出磷酸水解酶活性，但它是糖尿病中细胞介导的自身免疫的主要靶标。 已经描述了该基因的几种选择性剪接转录物变体，但尚未确定其生物学有效性。 [RefSeq 提供，2008 年 7 月] This gene encodes an Enzyme belonging to the glucose-6-phosphatase catalytic subunit family.

The G6PC1, G6PC2 and G6PC3 genes encode distinct glucose-6-phosphatase catalytic subunit (G6PC) isoforms. In mice, germline deletion of G6pc2 lowers fasting blood glucose (FBG) without affecting fasting plasma insulin (FPI) while, in isolated islets, glucose-6-phosphatase activity and glucose cyclin …

2009年10月23日 · Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate. It is a multicomponent system located in the endoplasmic reticulum that comprises several integral membrane proteins, namely a catalytic subunit (G6PC) and transporters for G6P, inorganic phosphate, and glucose.

G6pc2 is an autoantigen which is the natural target of a prevalent T-cell population causing insulin-dependent diabetes mellitus through destruction of pancreatic beta cells.

2014年7月31日 · G6PC2属于G6PC家族蛋白，G6PC2过度表达能增加G6P的活性。 其可能抑制参与葡萄糖利用和葡萄糖刺激的胰岛素分泌的葡萄糖激酶活性。 此外，在几种糖尿病动物模型中胰岛G6PC2活性增加。 本文主要介绍G6PC2基因多态性与血糖调节及糖尿病的联系和转录调节以及编码蛋白的生物学功能。 【关键词】 葡萄糖-6-磷酸酶催化亚基-2;基因多态性;糖尿病. 【Summary】 Glucose-6-phosphatase (G6P) catalyzes the hydrolysis of glucose 6-phosphate (G6P) to …