Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene. [5][6][7] This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family.

2025年1月1日 · Using α cell–specific gene ablation of G6pc2 in mice, we showed that this gene plays a critical role in controlling glucose suppression of amino acid–stimulated glucagon secretion independent of alterations in insulin output, islet hormone content, or islet morphology, findings that we confirmed in primary human α cells.

2024年12月25日 · G6PC2 (Glucose-6-Phosphatase Catalytic Subunit 2) is a Protein Coding gene. Diseases associated with G6PC2 include Glycogen Storage Disease Ia and Basophilic Adenocarcinoma. Among its related pathways are Gluconeogenesis and Glycolysis (REACTOME). Gene Ontology (GO) annotations related to this gene include glucose-6-phosphatase activity.

这些酶是催化 6-磷酸葡萄糖水解的多组分整合膜系统的一部分，这是糖异生和糖原分解途径的最终步骤，可将葡萄糖释放到血液中。 由该基因编码的家族成员存在于胰岛中，不表现出磷酸水解酶活性，但它是糖尿病中细胞介导的自身免疫的主要靶标。 已经描述了该基因的几种选择性剪接转录物变体，但尚未确定其生物学有效性。 [RefSeq 提供，2008 年 7 月] This gene encodes an Enzyme belonging to the glucose-6-phosphatase catalytic subunit family.

2025年2月1日 · Glycemic control is dependent on the activity of hepatic glucose-6-phosphatase catalytic subunit (G6PC)1 and pancreatic beta cell G6PC2 that both catalyze the hydrolysis of G6P to glucose. Mutations or SNPs in G6PC1 or G6PC2 can directly alter glucose regulation dynamics and cause disease phenotypes.

2013年3月19日 · Here we examine the effect of rs560887 on G6PC2 pre-mRNA splicing and the contribution of an additional common G6PC2 promoter SNP, rs2232316, to the association signal. Methods. Minigene analyses were used to characterise the effect of …

Results: The rs560887-G allele was shown to enhance G6PC2 pre-mRNA splicing, whereas the rs2232316-A allele enhanced G6PC2 transcription by promoting Foxa2 binding. Genetic analyses provide evidence for association of the rs2232316-A allele with increased FPG (β = 0.04 mmol/l; p = 4.3 × 10(-3)) as part of the same signal as rs560887, rs573225 ...

2018年3月7日 · We show that a single systemic injection of wild-type or native human G6PC mRNA results in significant improvements in fasting blood glucose levels for up to 7 days post-dose. These changes were associated with significant reductions in liver mass, hepatic G6P, glycogen, and triglycerides.

We found that deletion of G6pc2 led to ∼60% increases in glycolytic and citric acid cycle (CAC) fluxes at both 5 and 11 mM glucose concentrations. Furthermore, intracellular insulin content and GSIS were enhanced by approximately two-fold, along with increased cytosolic redox potential and reductive carboxylation flux.

G6PC2编码葡萄糖 6 磷酸酶 (G6Pase) 催化亚基，可调节胰岛素分泌对葡萄糖的敏感性，从而调节空腹血糖 (FBG)。rs560887 是G6PC2中常见的单核苷酸多态性 (SNP) ，是人类 FBG 变异性的重要决定因素。