2024年12月21日 · 眼底自发荧光（FAF）是一种无创成像技术，可通过采集LF在RPE细胞内的分布状态，客观反映ARMD的病情变化。 本文涵盖了FAF原理的介绍、ARMD中FAF成像的回顾，以及ARMD研究中FAF对地图状萎缩（GA）和早期ARMD表型的最新分类，并总结了ARMD发病过程中萎缩进展和脉络膜新生血管形成的关系。 眼底自发荧光原理. 自发荧光（AF）是指某些分子在被合适的波长光激发时发光的现象。 这些激发分子被称为荧光团，可分为外源性和内源性。 前 …

2025年1月2日 · FAF in GA is locally multifactorial, with photoreceptor shortening potentially promoting hyperFAF by increasing incoming excitation light available to RPE fluorophores. RPE dysmorphia may lead to either longer or shorter pathlength for excitation light.

Geographic atrophy (GA) is a late-stage phenotype of age-related macular degeneration (AMD) that causes dense scotomatas, reading and facial recognition challenges, and poor visual acuity when affecting the fovea. 1 In the United States, nearly 1.5% of the population older than 40 years have late AMD, including GA. 2 No effective treatments curr...

Abnormal FAF outside GA in 149 eyes was classified into four patterns: focal (12.1%), banded (12.8%), patchy (2.0%), and diffuse (57.0%), whereby 12.1% had normal background FAF in the junctional zone. In 4% there was no predominant pattern.

Fundus autofluorescence (FAF) imaging has been shown to be helpful in predicting progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). We assess the ability of FAF imaging to predict rate of GA progression using a simple categorical scheme.

In the context of the Fundus Autofluorescence in Age-Related Macular Degeneration (FAM) Study, patients with diffuse-trickling GA were examined and characterized by FAF and spectral-domain optical coherence tomography imaging.

2021年8月16日 · Various biomarkers assessed using fundus autofluorescence (FAF) and spectral-domain optical coherence tomography have been associated with GA progression, including subretinal drusenoid...

GA diagnosis is confirmed by clinical examination using a high-definition fundus lens for stereo biomicroscopy, as well as being noted on fluorescein angiography. 7 As noted above, FAF imaging and spectral-domain optical coherence tomography have made it easier to diagnose GA, particularly early signs of GA, as these imaging modalities can ...

2015年9月15日 · We know that geographic atrophy (GA) is an important cause of severe, irreversible vision loss in patients with AMD. When lipofuscin is absent due to RPE cell loss and death, as in the case with GA, the FAF signal drastically decreases. FAF allows a more dramatic visualization of areas of atrophy than standard fundus photography.

Purpose: To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age-related macular degeneration (AMD). Design: Prospective longitudinal multicenter natural history study.