
“咱就是说” 谁看完这篇文章还不懂自噬抑制剂 - 知乎
半胱氨酸蛋白酶atg4b执行两个lc3/gabarap处理事件:启动新合成的pro-lc3/gabarap以实现脂化(新翻译的lc3b,称为pro-lc3,在c-末端被半胱氨酸蛋白酶atg4b切割,得到lc3-i)和在自溶酶体中 …
LC3/GABARAP 家族蛋白:自噬(非)相关功能,The FASEB Journal …
2016年9月6日 · LC3B 是研究最多的家族蛋白,与自噬体的发育和成熟有关,用于监测自噬活性。 鉴于高度同源性,通常假定其他 LC3/GABARAP 家族蛋白具有相似的功能。 尽管如此,大量 …
LC3/GABARAP family proteins: autophagy-(un)related functions
In this review, we discuss the current knowledge and functions of the LC3/GABARAP family proteins. We focus on processing of the individual family proteins and their role in autophagy …
<br>GABARAP蛋白家族自噬和非自噬功能的新视角:人类疾病的 …
GABARAP subfamily proteins (GABARAPs) share a high degree of homology with LC3 family proteins, and their unique roles are often overlooked. GABARAPs are as indispensable as …
Critical assessment of LC3/GABARAP ligands used for degrader
2024年11月25日 · Through this study, we identified diverse validated LC3/GABARAP ligands and fragments as starting points for chemical probe and ATTEC development. Targeted protein …
<br>用于降解剂开发的 LC3/GABARAP 配体和 LC3/GABARAP 结 …
ATTEC 基于对 LC3/GABARAP 靶标的募集,LC3/GABARAP 是一个泛素样蛋白家族,可能与自噬体膜结合并将负载货物的自噬受体拴在自噬体中。 在这项工作中,我们严格测试了已报道的 …
LC3/GABARAPs drive ubiquitin-independent recruitment of
2019年1月24日 · Current models of selective autophagy dictate that autophagy receptors, including Optineurin and NDP52, link cargo to autophagosomal membranes. This is thought to …
LC3/GABARAP family proteins: autophagy-(un)related functions
2016年9月6日 · Pulldown of ectopically expressed LC3/GABARAP family proteins revealed that GABARAP and GABARAPL1 display highest affinity to ULK1 and LC3B the lowest. This …
LC3/GABARAP family proteins: autophagy-(un)related functions
In this review, we discuss the current knowledge and functions of the LC3/GABARAP family proteins. We focus on processing of the individual family proteins and their role in autophagy …
lc3蛋白和gabarap蛋白 - 百度文库
lc3蛋白和gabarap蛋白是两种重要的自噬相关蛋白,在细胞自噬过程中起着重要的作用。 本文将介绍它们的结构、功能和相互关系。 一、LC3蛋白