Substrate Channeling via a Transient Protein-Protein Complex: The …
2020年6月26日 · We analyzed the mechanism of NADH-channeling from D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to L-lactate Dehydrogenase (LDH) using enzymes from …
【文献翻译】GAPDH:一种功能不寻常的普通酶 - 知乎
2023年6月3日 · GAPDH的主要作用是糖酵解级联中甘油醛-3-磷酸 (G3P)的酶促转化，这是葡萄糖代谢的一个必要步骤。 这发生在细胞质中，尽管GAPDH可以穿梭进入细胞核 (可能依赖于翻 …
（1）GAPDH的功能作用？ - 知乎
GAPDH能够结合mRNA 3′UTR中的AU丰富元素，这一活性据报道可能导致两种结果：一方面，它可能导致mRNA稳定，从而促进翻译，就像GAPDH结合卵巢癌细胞中的集落刺激因 …
糖酵解过程及中的重要酶类及其调控（二） - 知乎
更加多功能的是GAPDH。 GAPDH不仅可以进入细胞核，还能进入线粒体及多种膜结构，并可以与细胞骨架相互作用。 GAPDH的非糖酵解功能包括细胞死亡、自噬、DNA修复、tRNA出核、 …
Determining the quantitative relationship between glycolysis and GAPDH ...
2021年1月1日 · Here, using siRNA-mediated knockdown of GAPDH expression and iodoacetate-dependent inhibition of enzyme activity, we examined the quantitative relationship between …
Interaction between mammalian glyceraldehyde-3-phosphate dehydrogenase ...
2006年5月15日 · We found that GAPDH interacts with heart or muscle isozymes of LDH with approximately one-to-one stoichiometry. The interaction is specific; GAPDH shows interaction …
通过瞬时蛋白质-蛋白质复合物的底物通道：D-甘油醛-3-磷酸脱氢 …
We analyzed the mechanism of NADH-channeling from D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to L-lactate Dehydrogenase (LDH) using enzymes from different …
Substrate Channeling via a Transient Protein-Protein Complex
2020年6月26日 · We analyzed the mechanism of NADH-channeling from D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to L-lactate Dehydrogenase (LDH) using enzymes from …
Computer Simulations of NAD Channeling between GAPDH and LDH
2013年1月29日 · Herein, Brownian dynamics (BD) elucidates the interactions between the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate …
GAPDH inhibits intracellular pathways during starvation for …
2018年9月12日 · Here we reveal that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibits coat protein I (COPI) transport by targeting a GTPase-activating protein (GAP) towards …