GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded …

2024年12月25日 · GATA1 (GATA Binding Protein 1) is a Protein Coding gene. Diseases associated with GATA1 include Thrombocytopenia With Beta-Thalassemia, X-Linked and Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities.

2017年4月13日 · Acquired and inherited GATA1 mutations contribute to Diamond-Blackfan anemia, acute megakaryoblastic leukemia, transient myeloproliferative disorder, and a group of related congenital dyserythropoietic anemias with thrombocytopenia.

The GATA1 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and helps control the activity of many other genes. On the basis of this action, the GATA1 protein is known as a transcription factor.

该蛋白通过调节胎儿血红蛋白向成人血红蛋白的转换，在红细胞发育中发挥重要作用。 该基因的突变与 X 连锁红细胞生成异常性贫血和血小板减少症有关。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of …

2025年1月4日 · Gene target information for GATA1 - GATA binding protein 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

GATA1 is a prototypical lineage-restricted transcription factor that is central to the correct differentiation, proliferation and apoptosis of erythroid and megakaryocytic cells.

GATA-1是最早发现的GATA家族成员,表达在早期红系细胞、巨核细胞、嗜酸性粒细胞、肥大细胞、睾丸基质Sertoli 细胞及非造血胚胎干细胞中.转录因子GATA-1在正常红细胞增殖、分化过程中起重要的生物学作用,且控制着巨核细胞、肥大细胞和嗜酸性细胞的分化.转录因子 ...

GATA1是最早发现的GATA家族成员,表达在早期红系细胞,巨核细胞,嗜酸性粒细胞,肥大细胞,睾丸基质Sertoli细胞及非造血胚胎干细胞中.转录因子GATA-1在正常红细胞增殖,分化过程中起重要的生物学作用,且控制着巨核细胞,肥大细胞和嗜酸性细胞的分化.转录因子GATA-1可以 ...

由于GATA1可激活血红素合成，GATA1和血红素一起介导红细胞的成熟，血红素又可终止GATA1的合成，本研究揭示了GATA1-血红素自调节回路，提示GATA1和血红素是红细胞正常分化过程的共同主调控因子。