GATA4 is a critical transcription factor for proper mammalian cardiac development and essential for survival of the embryo. GATA4 works in combination with other essential cardiac transcription factors as well, such as Nkx2-5 and Tbx5.

2024年12月25日 · GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include Testicular Anomalies With Or Without Congenital Heart Disease and Atrial Septal Defect 2. Among its related pathways are Gene expression (Transcription) and Cardiac conduction.

2024年4月23日 · In this study, we identify GATA4 as a tumor suppressor in the invasion and migration of breast cancer. Functionally, GATA4 significantly reduces the transcription of MMP9. On a mechanistic...

2014年9月24日 · Here, we addressed this question by mapping chromatin occupancy of GATA4—a master cardiac transcription factor—in heart development and disease. We find that GATA4 binds and participates in...

GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma. The M310T mutation in the GATA4 gene is a novel pathogenic target of the familial atrial septal defect.

GATA4是转录因子GATA家族的重要一员，目前研究已经证实， 它对心肌肥厚的进程有着重要的影响。本文主要综述转录因子GATA4在CH和HF进程中调节机制的研究 进展。 关键词 心力衰竭，心肌肥厚，GATA4 Research Progress on the Correlation and Molecular Mechanism of …

2022年8月8日 · Here, we show that GATA4 (GATA-binding protein 4), a cardiac-enriched zinc finger–containing, DNA-binding transcription factor essential for normal cardiac development in mice and humans, and for mediation of the transcriptional response to cardiac stress, 26–28 also functions as a regulator of alternative RNA splicing.

gata3、gata4和gata6可以抑制过多的外胚层谱系标记，以促进成功的重编程，从而凸显了多能性维持必需的不同谱系特异力量之间的调整平衡。 然而，谱系特异性线索与多能性激活之间的联系，仍然还不明确。

关于 gata4 Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,676,935-11,760,002 (from NCBI) This gene has 8 transcripts (splice variants), 1 gene allele, 206 orthologues, 7 paralogues and is associated with 15 phenotypes.

具有多种功能，包括DNA结合转录因子活性，RNA聚合酶II特异性；NFAT蛋白结合活性；以及顺式调控区序列特异性的DNA结合活性。 参与多种过程，包括心肌细胞发育中的细胞生长；BMP信号通路的正调控；以及转分化。 位于细胞核中。 用于研究心肌梗死。 先天性心脏病和肺动脉高压的生物标志物。 此基因的人类同源物与先天性心脏病（多种）有关。 与人类GATA4（GATA结合蛋白4）正交。 [由基因组资源联盟，2022年4月提供] Dir./Indir. Glycine N-methyltransferase is …