胶质母细胞瘤（GBM）是颅脑最常见的恶性胶质瘤，其在基因分子水平诊断上分两种，分为IDH野生型和IDH突变型，IDH突变即为为异柠檬酸脱氢酶突变，是在这种肿瘤中发现的最重要的遗传改变之一。 该文主要着重在对IDH突…

2024年12月29日 · Glioblastomas, now defined as IDH-wildtype tumors, are essentially tumors of adults, usually occurring after the age of 40 years with a peak incidence between 65 and 75 years of age. There is a slight male preponderance with a 3:2 M:F ratio 5.

2020年4月15日 · In glioma, IDH mutations are recognised in >80% of World Health Organisation (WHO) grade II/III cases. 7 In WHO grade IV glioblastoma (GBM), IDH mutations are also found frequent in secondary...

As a result, GBM now refers specifically to the most aggressive form of isocitrate dehydrogenase (IDH)-wildtype diffuse adult-type astrocytoma, for which O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is prognostic.

IDH野生型GBM有时也被称为“IDH野生型原发性胶质母细胞瘤”，以区别于IDH突变型GBM，后者是由低级IDH突变型星形细胞瘤引起的。 临床特点. GBM可以发生在任何年龄（包括新生儿和婴儿），但最高年龄为55-85岁。 IDH野生型GBM倾向于发生在老年人（峰值年龄在60至75岁之间），而IDH突变型GBM则早于十年或两年。 男女发病比基本上相等。 临床表现随位置而异，癫痫发作、局灶性神经功能缺损和精神状态改变是最常见的症状。 颅内压升高引起的头痛也很常 …

Glioblastoma (GBM), the most lethal primary brain malignancy, is divided into histological (hist-GBM) and molecular (mol-GBM) subtypes according to the 2021 World Health Organization classification of central nervous system tumors. This study aimed ...

2022年1月1日 · Glioblastoma multiforme (GBM) is the most malignant primary brain tumor found in humans. Mutations in isocitrate dehydrogenases 1 (IDH1 R132H) was observed in GBM. GBMs with IDH1 R132H have longer patient survival compared to GBMs with wild-type IDH1 and identifying the mechanism of this can contribute to the development of a new treatment for GBM.

2024年5月4日 · GBM（ molGBM），最新的中枢神经系统肿瘤分类将 molGBM归为“IDH-wt GBM（WHO 4级）”[7]。分析 病理诊断为GBM病例的基因表达状态，对肿瘤的分 类与诊断及肿瘤分子特点的进一步阐述具有重要意 义[8]。本研究分析了74例病理学诊断为GBM的病

2022年7月6日 · 研究显示，超过80%的低级别胶质瘤（LGG）存在IDH突变，而仅有5%的原发GBM存在IDH突变。 IDH野生型胶质瘤较IDH突变型胶质瘤预后差，例如IDH野生型LGG的中位OS和PFS仅为22.8月和8.4月，接近GBM的预后。 新的cIPMACT-NOW分类中，建议将IDH野生型LGG重新分类为：弥漫性星形胶质瘤，具有胶质母细胞瘤分子特征的IDH野生型胶质瘤。 另外，NCCN指南建议，采用GBM的标准治疗方案治疗IDH野生型LGG。 鉴于目前学术界对IDH野 …

In the past, glioblastomas were categorized as either IDH mutant or IDH-wildtype. The 2021 World Health Organization (WHO) update on CNS tumor classifications defined glioblastomas as IDH-wild type. (IDH mutant tumors that were previously classified as glioblastoma are now classified as astrocytoma, IDH mutant, grade 4.)