Multiple Roles of the Stress Sensor GCN2 in Immune Cells
The GCN2 signaling pathway plays a major role in autophagy and the regulation of stress-induced autophagy gene expression. The GCN2 kinase and its downstream transcription factors, ATF4 …
General control nonderepressible 2 (GCN2) as a therapeutic target …
Overview of GCN2 protein domains and factors that activate GCN2. Active GCN2 phosphorylates the α subunit of eukaryotic translation initiation factor 2 which reduces global protein …
Q9P2K8 - UniProt
Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, …
GCN2 kinase activation by ATP-competitive kinase inhibitors
2021年12月23日 · A genome-wide CRISPR screen revealed that loss of general control nonderepressible 2 (GCN2) kinase increases cellular resistance to the pan-ErbB inhibitor …
851877 - Gene ResultGCN2 serine/threonine-protein kinase GCN2 []
2025年2月8日 · GCN2 is required for nitrogen catabolite repression-sensitive nuclear Gln3 localization. Gcn2 functions upstream of Ure2. Mutations leading to amino acid substitutions …
Global phosphoproteomics pinpoints uncharted Gcn2-mediated …
2021年5月6日 · The Gcn2 kinase mediates cellular adaptations to amino acid limitation through the translational control of gene expression that is primarily executed by eIF2α …
The GCN2 eIF2α Kinase Is Required for Adaptation to Amino …
To determine the potential role of GCN2 in the regulation of amino acid biosynthesis in higher eukaryotes, we have isolated the mouse Gcn2 gene and have generated a Gcn2 −/− knockout …
Multiple mechanisms activate GCN2 eIF2 kinase in response to …
2024年1月28日 · The eIF2 kinase GCN2 is a first responder in the ISR that is activated by amino acid depletion and other stresses not directly related to nutrients. Two mechanisms are …
GCN2: roles in tumour development and progression - PubMed
2022年4月29日 · GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. …
The clinical antiprotozoal drug halofuginone promotes weight loss …
5 天之前 · In such stress situations, GCN2 activation helps to reprogram gene expression to favor catabolic processes, preparing the organism to better cope with nutrient deficit (37, 38). This …