Multifaceted role of GCN2 in tumor adaptation and
2024年11月1日 · Similarly, in HeLa cells, kynurenine presence hinders cystine uptake but activates GCN2, enhancing ATF4 translation and SLC7A11 expression, increasing cystine …
Activation of the integrated stress response by inhibitors of its ...
2023年9月8日 · Reconstitution of ISR activation with recombinant proteins demonstrates that PERK and PKR inhibitors directly activate dimeric GCN2, following a Gaussian activation …
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic …
GCN2/eIF2αK4 is exclusively seen as an eIF2α kinase, which regulates reprogramming of protein translation in response to stress. Here, we show that GCN2 has an unexpected role in …
Multiple mechanisms activate GCN2 eIF2 kinase in response to …
2024年1月28日 · The eIF2 kinase GCN2 is a first responder in the ISR that is activated by amino acid depletion and other stresses not directly related to nutrients. Two mechanisms are …
The ribosomal P-stalk couples amino acid starvation to GCN2 ... - eLife
2019年11月21日 · Genetic lesions that compromise the ribosome P-stalk implicate direct signalling from the ribosome to the translation initiation factor eIF2 kinase GCN2 in the cellular …
Cellular responses to halofuginone reveal a vulnerability of the GCN2 …
Halofuginone (HF) is a phase 2 clinical compound that inhibits the glutamyl‐prolyl‐tRNA synthetase (EPRS) thereby inducing the integrated stress response (ISR). Here, we report that …
权威PNAS新发现：氨基酸传感器GCN2通过调节肝巨噬细胞控制红 …
2023年9月20日 · GCN2是在所有真核生物中发现的最进化保守的eIF2AK，其功能是通过调节细胞类型特异性功能来调节生理和病理进程，包括代谢、免疫、癌症等。 与此同时一些证据表 …
Cell子刊：激活GCN2，可代谢重编程T细胞，增强其抗肿瘤免疫
使用GCN2激动剂halofuginone（halo）激活氨基酸饥饿反应可以增强T细胞代谢及其抗肿瘤活性。 多伦多大学的研究人员在 Cell 子刊 Cell Reports Medicine 上发表了题为：Ex vivo activation …
2023年6月9日 · Here, we show that GCN2 is a novel regulator of chromosome alignment. The function of GCN2 is not through the regulation of mitotic translation. Instead, we identify PP1c …
GCN2 knockout does not interfere with transgene reactivation in HeLa …
GCN2 knockout does not interfere with transgene reactivation in HeLa cells. (A) Immunoblotting of protein extracts from the HeLa-OA1 parental cell line and GCN2-KO clones 183#11, 185#5...