GCN2 contributes to mTORC1 inhibition by leucine deprivation …
Jun 14, 2016 · Our data establish that GCN2 is involved in the inhibition of mTORC1 upon leucine or arginine deprivation. However, the activation of GCN2 alone is not sufficient to inhibit …
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination …
Dec 5, 2023 · Mammalian target of rapamycin complex 1 (mTORC1) monitors cellular amino acid changes for function, but the molecular mediators of this process remain to be fully defined. …
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination …
Dec 5, 2023 · Herein, we identify a novel amino-acid-sensing mechanism of mTORC1 that utilizes uncharged transfer RNA (tRNA)-mediated general control nonderepressible 2 (GCN2) …
Phosphorylation of GCN2 by mTOR confers adaptation to …
Aug 1, 2024 · We identified a labile physical interaction between GCN2 and mTOR that results in a phosphorylation of GCN2 on serine 230 by mTOR, which promotes GCN2 activity. When …
Cell子刊：沈少明/陈国强/苏冰合作揭示mTORC1感应氨基酸的普适 …
Nov 19, 2023 · 该研究首次发现细胞内各种氨基酸浓度的改变可以统一地通过mTOR泛素化来被细胞感知，并进一步在机制上详细解释了mTORC1广泛感知所有氨基酸浓度波动的原理。 我们 …
GCN2和mTORC1信号路径对动物机体氨基酸平衡的调节作用
Sep 1, 2017 · GCN2路径能有效感应胞内氨基酸缺乏，而mTORC1路径则能对胞外氨基酸水平的变化做出响应。 本文结合近年来有关GCN2和mTORC1的研究进展，阐述了氨基酸充足和氨基 …
氨基酸信号对mtor和gcn2通路的影响研究进展 - 道客巴巴
Dec 14, 2016 · 雷帕霉素靶蛋白 (mtor) 和一般性调控阻遏蛋白激酶 2(gcn2) 作为重要的信号转导分子，位于蛋白质合成与降解过程中整个信号通路的中心位点，是调控该过程的重要通路，并对 …
Multiple Roles of the Stress Sensor GCN2 in Immune Cells
We also discuss the antagonism of GCN2 and mTOR pathways in immune cells. A better understanding of GCN2′s functions and signaling pathways in the immune system under …
Amino acid availability governs mTOR ubiquitination
Dec 15, 2023 · Depletion of GCN2 abolished amino acid depletion-induced mTOR ubiquitination and FBXO22 translocation. Mechanistically, GCN2 could directly phosphorylate FBXO22 at …
Phosphorylation of GCN2 by mTOR confers adaptation to …
We identified a labile physical interaction between GCN2 and mTOR that results in a phosphorylation of GCN2 on serine 230 by mTOR, which promotes GCN2 activity. When …