The GCN5: its biological functions and therapeutic potentials
2021年1月15日 · General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of the most highly studied histone acetyltransferases. It acts as both histone …
KAT2A Gene - GeneCards | KAT2A Protein | KAT2A Antibody
2024年12月25日 · KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) …
肿瘤表观遗传第三讲——组蛋白乙酰化 - 知乎 - 知乎专栏
在人类中有三个主要的HAT家族被充分研究，包括GNAT (HAT1, GCN5, PCAF)， MYST (Tip60, MOF,MOZ, MORF, HBO1)和p300/CBP。 不可避免的是，HATs也可以催化广泛的非组蛋白的 …
Nature Plants | 何新建团队发现植物中两个GCN5组蛋白乙酰化酶 …
GCN5 是第一个被发现的组蛋白乙酰化酶，它以多亚基蛋白复合体的形式发挥功能，参与基因的转录激活（Brownell et al., 1996）。 真核生物中已发现的包含GCN5的蛋白复合体包括：物种间 …
The acetyltransferase GCN5 contributes to neuroinflammation in …
2025年3月4日 · The acetyltransferase GCN5 is implicated in various diseases involving inflammation in peripheral tissues. Cho et al. found that GCN5 mediates inflammation in the …
The Gcn5 lysine acetyltransferase mediates cell wall remodeling ...
5 天之前 · The GCN5-dependent comparative transcriptomic analysis between C. auris and C. albicans showed that pathways such as sphingolipid metabolism and GPI anchor biosynthesis …
GCN5：其生物学功能和治疗潜力,Clinical Science - X-MOL
在这篇综述中，我们讨论了结构特征，GCN5 的生物学功能以及与其不平衡相关疾病的机械联系。 此外，将从药物化学的角度介绍目前的 GCN5 调节剂及其局限性。 一般控制不可抑制 5 …
Histone acetyltransferase Gcn5 regulates gene expression by …
2020年9月1日 · Gcn5 indirectly regulate the expression of 114 genes by promoting the transcription of SET1. Many chromatin modifying factors regulate gene expression in an as-yet …
GCN5-targeted dual-modal probe across the blood-brain barrier …
2025年3月8日 · GCN5 is highly expressed in high-grade gliomas. To identify significant molecular markers for the malignant evolution of gliomas, we analyzed clinical information and transcript …
The Gcn5 lysine acetyltransferase mediates cell wall ... - PubMed
5 天之前 · Here, we show that C. auris GCN5 lysine acetyltransferase is essential for cell wall remodeling, antifungal drug resistance, and virulence. The Candida albicans GCN5 has …