
Human intraepithelial lymphocytes | Mucosal Immunology - Nature
2018年4月20日 · The location of intraepithelial lymphocytes (IEL) between epithelial cells, their effector memory, cytolytic and inflammatory phenotype positions them to kill infected epithelial...
Science | 调节肠道感知营养的细胞——γδ T细胞 - 知乎
2021年3月19日,来自耶鲁大学的 Ruslan Medzhitov 在 Science 杂志发表文章, γδ T cells regulate the intestinal response to nutrient sensing, 通过对小鼠进行碳水化合物饮食和蛋白质 …
γδ T cells in homeostasis and host defence of epithelial barrier ...
In this review we focus on the γδ IEL compartment in the two largest epithelial tissues in the body, namely the epidermis and intestine, with particular emphasis on the murine system, and …
gd IEL depend on pathogen sensing by ECs. Direct modulation of glycolysis is sufficient to change gd IEL behavior and susceptibility to early pathogen invasion. Our results uncover a …
press the gd T-cell receptor (gd IELs) limit pathogen trans-location across the intestinal epithelium by unknown mechanisms. We investigated whether gd IEL migration and interaction with …
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s ...
2025年3月21日 · Tissue-resident intraepithelial lymphocytes (IELs) are highly responsive to intestinal infection, injury, and inflammation (9, 10).IELs are largely characterized by their …
上皮内淋巴细胞 - 百度百科
②约60%的iel为胸腺非依赖性,主要为γδ t细胞。 这类T细胞可能以造血前体的形式,不经胸腺而直接由骨髓迁移至肠上皮,并在肠上皮提供的微环境中分化成熟。
γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial …
Based on their cytolytic capacity and surveillance behavior, we investigated whether intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IELs) are actively involved in the shedding …
上皮内淋巴细胞 (IEL) 区室的扩张导致 γδ IEL 中的生物能谱增加并 …
我们最近发现了一种可传播的过度增殖性 γδ iel (γδ hyp) 表型,可以防止肠道感染,并且这些小鼠没有明显的肠道病理迹象。鉴于 iel 在代谢上受到限制以防止异常激活,我们假设 γδ hypiel 的 …
Sci Immu | γδ T细胞如何发育和产生免疫反应 - 知乎
2023年7月22日 · γδT细胞是一种既能杀伤癌细胞,肿瘤干细胞,又能识别癌抗原的免疫细胞。 大多数γδT细胞为 CD4-CD8-,即其细胞表面不表达CD4和CD8分子,但有少数可表达CD4 …