Study of an N6-methyladenosine- and ferroptosis-related …
Feb 18, 2025 · This study aimed to establish a prognostic framework centered on genes associated with m6A and ferroptosis to enhance the accuracy of prognosis predictions for neuroblastoma (NB) patients, thereby improving targeted therapeutic strategies.
RNA甲基化修饰（1）——m6A概念 | m6A专题 - 知乎
m6A能够加速mRNA前体的加工时间，加快mRNA在细胞中的转运速度和出核速度。 除了m6A，RNA上还存在以下常见的几种修饰，包括m1A，m5C等（图1）。 已知tRNA上发生碱基修饰的比例较高，会有各种各样的碱基修饰行为。
Nat Rev Genet（IF=60）| m6A最新综述！总结m6A参与调节的生 …
鉴于m6A在维持体内平衡方面的广泛作用，当m6A的调节出错时，就会发生癌症等疾病。 该综述重点讨论m6A的三个新角色:神经元突触功能和神经行为;T细胞稳态与免疫应答以及癌症干细胞的建立。
Decoding the interplay between m6A modification and stress
Nov 15, 2024 · Our results suggest a mechanism for the interplay between m 6 A modification and SG through YTHDF2 regulation. N6 -methyladenosine (m 6 A) is the most abundant internal modification of various types of RNAs and regulates RNA transcription (1, 2), splicing (3), transport (4), decay (5), and translation (6, 7).
Dissecting the sequence and structural determinants guiding m6A ...
Feb 15, 2024 · N6-methyladenosine (m6A) is the most abundant mRNA modification, and controls mRNA stability. m6A distribution varies considerably between and within species. Yet, it is unclear to what extent this variability is driven by changes in genetic sequences (‘cis’) or cellular environments (‘trans’) and via which mechanisms.
The role of m6A modification in the biological functions and
Feb 21, 2021 · N 6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic...
Decoding the m6A epitranscriptomic landscape for …
Jan 18, 2025 · Here, we introduce pum6a, an innovative attention-based framework that integrates positive and unlabeled multi-instance learning (MIL) to address the challenges of incomplete labeling and missing...
m6A ‘encodes’ a dedicated mRNA decay pathway - Nature
Dec 3, 2024 · Sites of N6-methyladenosine (m6A) in the coding region of mRNAs can induce a distinct, translation-dependent decay pathway involving mRNA translocation to P-bodies.
关于易基因RNA m6A甲基化测序(MeRIP-seq)技术 - 博客园
Dec 11, 2024 · 本研究首先揭示了m6A RNA reader蛋白YTHDF2在早期效应或效应样CD8 T细胞中高表达。 分析结果表明YTHDF2促进了新生RNA（nascent RNA）合成，而m6A识别对于蛋白质特异性核功能至关重要，也加强了其在RNA水平上的自我调控。 T细胞中YTHDF2缺失会加剧肿瘤进展，并导致对PD-1阻断在小鼠和人类中的无反应性。 除了启动对线粒体健康必要的RNA衰变外，YTHDF2还协调染色质变化，促进T细胞的多功能性。 YTHDF2与IKZF1/3互作，促进目标 …
A combined deep learning framework for mammalian m6A site …
Dec 11, 2024 · In this study, we developed an m6A site predictor called deepSRAMP, which integrates sequence-based and genome-derived features into the combination structure of a Transformer encoder and a recurrent neural network (RNN) for learning contextual representatives of proximal regions around m6A sites.