2024年12月27日 · We propose that GD3 acts as a senescence immune checkpoint (SIC) that allows senescent cells to escape immunosurveillance and to trigger immune anergy during aging. Advancing age goes hand in...

They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting...

2024年12月29日 · 近日，国际著名杂志Cancer Research在线刊登了德国伯恩大学研究者的最新研究成果“Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer，”文章中，研究者揭示了在卵巢癌中，新分子GD3可以作为先天免疫效应的一个抑 …

GD3 synthase (GD3S) is the only enzyme that regulates the biosynthesis of GD3 and GD2 and therefore exerts a significant effect on cancers. In this review, we present the classification of gangliosides, the physiological and pathological significance of gangliosides in humans, the roles of GD3 and GD2 in cancers, and the potential of GD3S to ...

The adsorption of humic acid (HA) on an Al2O3 surface in the presence of Gd3+ was studied in situ by quartz crystal microbalance with dissipation (QCM-D) and ex situ by ellipsometry and XPS. Adsorption of a HA/Gd3+ complex yielded an adlayer of a mass of 354 ng cm−2, the adlayer is characterized by a relativ

在本研究中，开发了一种通过将nanoparticles纳米颗粒（GdNP）和原卟啉IX（PpIX）双重封装到脂质体中来实现高级治疗疗法的新方法。 因此，将脂质体用于GdNP和PpIX的封装，其将被称为“ Gd-PpIX-NI”。 由于它们的高生物相容性，物理和化学稳定性以及合理的价格，因此选择了脂质体作为包封材料。 另一方面，GdNP和PpIX是放射治疗（RT）的良好敏化剂，特别是卟啉结构是光动力疗法（PDT）研究最多的药物之一。 在这项研究中，通过使用人类肺泡II型（ATII）样细 …

GD3 Ganglioside is an inducer of mitochondrial permeability. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. GD3 ganglioside is rapidly synthesized from accumulated ceramide after the clustering of death-inducing receptors and triggers apoptosis [1]. Room temperature in continental US; may vary elsewhere.

Application of the azidosphingosine glycosylation procedure furnished GD3 (1) in high overall yield. Comparison of synthetic GD3 with bovine-brain-derived GD3 showed that there were similar effects in GD3-triggered uncoupling of mitochondrial respiration and in induction of apoptosis in oligodendrocytes.

Medium sized molecules endowed with multiple Gd 3+ complexes are efficient high magnetic field MRI contrast agents. The novel ligand Mes (DO3A) 3, presenting three DO3A (1,4,7,10-tetraazacyclododecane- N, N ′, N ′′-triacetatic acid) units grafted on the methyl positions of a central mesitylene (1,3,5-trimethylbenzene), has been synthesized.

神经节苷脂gd3合成酶为潜在肿瘤治疗靶标的研究. 负责人：王金华. 依托单位：中国医学科学院药物研究所. 批准年份：2015