Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] GDF11 is a member of the Transforming growth factor beta family. [6] GDF11 acts as a cytokine and its sequence is highly conserved between in humans, mice and ...

生长分化因子11（growth differentiation factor-11，GDF11）是 转化生长因子β （transforming growth factor-β, TGF-β）超家族中 骨形态发生蛋白 （bone morphogenetic proteins, BMPs）亚家族中的一个重要成员，在哺乳动物的骨骼、肾等多种器官组织上均有表达，除了与哺乳动物的抗衰 …

2024年12月25日 · GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Vertebral Hypersegmentation And Orofacial Anomalies and Orofacial Clefting Syndrome. Among its related pathways is …

2023年3月19日 · 本文发现外周腹腔注射gdf11可抑制mtor信号，增强海马神经元自噬信号，激活神经元明显改善老年相关的学习记忆和抑郁样行为。

The cause of this anti-aging phenomenon remained a mystery until May 2013, when Wagers, PhD, and cardiologist Richard Lee, MD, found that a protein in the blood of young mice, called GDF11, was able to quickly reverse symptoms of heart failure in older mice.

2023年11月17日 · In mice, selective knock-out of GDF11 in the post-mitotic EN shapes the brain ageing-related transcriptional profile, induces EN senescence and hyperexcitability, prunes their dendrites, impedes...

这两篇文章分别阐述了 明星分子 GDF11（growth differentiation factor 11）在不同来源（骨髓和心脏）的 间充质干细胞 中的作用。他们发现GDF11具有增强干细胞活性、促进细胞分泌生长因子、提高分化效率等功能，明确了GDF11在促进血管生成，治疗缺血性疾病中的作用。

2025年2月8日 · Serum growth differentiation factor 11 is closely related to metabolic syndrome in a Chinese cohort. GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells. GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling.

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength.

GDF11在有核红细胞中高表达，促进终末期骨髓无 效造血；人体GDF11及TGF βs阻断剂RAP 011、 RAP 536（对应小鼠体内的ACE 011、ACE 536），可