Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily .

GDF-9 regulates ovarian function, and plays a vital role for fertility. GDF-9 is mainly expressed in the oocytes of ovarian follicles, and some testicular and hypophyseal expression has been detected. GDF-9 is normally secreted by oocytes, and promotes the growth, development, and survival of human ovarian follicles.

2023年12月16日 · Bone morphogenetic protein (BMP15) and growth differentiation factor (GDF9) are critical for ovarian follicular development and fertility and are associated with...

2024年12月25日 · GDF9 (Growth Differentiation Factor 9) is a Protein Coding gene. Diseases associated with GDF9 include Premature Ovarian Failure 14 and Mitochondrial Complex Iii Deficiency, Nuclear Type 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Growth differentiation factor 9 inhibits vascular endothelial growth factor expression in human granulosa cells. A variant of human growth differentiation factor-9 that improves oocyte developmental competence. It was observed a statistically significant difference in genotype distribution of BMP15:c.852C>T between group POI and controls (p < 0 ...

Growth Differentiation Factor 9 (GDF9) is the first oocyte-derived growth factor required for ovarian somatic cell function in vivo. Gdf9 mRNA is expressed exclusively in oocytes in all species examined, but there appear to be important species differences in the timing of expression and roles of Gdf9/GDF9 between mice and other mammals.

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。 这种蛋白质调节卵巢功能。 该基因的表达减少可能与多囊卵巢综合征有关，并且该基因的突变在异卵双胞胎的母亲中可能更为常见。 [RefSeq 提供，2016 年 7 月] This gene encodes a secreted ligand of the TGF-beta (transforming growth …

生长分化因子gdf9属于生长分化因子-β超家族,它与其他成员有着很大的区别.它仅在卵巢或卵母细胞中表达,对卵泡生长发育和生殖功能等有着重要影响.笔者综述了gdf9基因的研究现状.

Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-beta superfamily that includes TGF-beta, activin, and bone morphogenetic proteins (BMPs). GDF-9 is indispensable for the development of ovarian follicles from the primary stage, and treatment with GDF- …

2024年3月7日 · GDF9（Growth Differentiation Factor 9）是一种重要的生长分化因子，属于TGF-β超家族。它在生物体内扮演着至关重要的角色，特别是在发育过程中起着关键作用。GDF9的重组蛋白被广泛用于研究生殖生物学领域、生殖医学和辅助生殖技术等方面。 GDF9基本信息： 1.