2021年2月25日 · This implies a coupling of P-loop disorder with E245 rotation in the GDP dissociation process and, conversely, a role for E245 in maintaining a stable GDP-bound G-protein conformation,...

This implies a coupling of P-loop disorder with E245 rotation in the GDP dissociation process, and conversely a role for E245 in maintaining a stable GDP-bound G protein conformation, which...

We identified three residues in the GDP-bound Gαi, including two SW-III residues (E236, D237) and one α3 residue (E245), that appear to play a key role in pH-dependent stability and conformational dynamics.

2020年8月11日 · We propose a detailed allosteric mechanism for GDP release, providing new insights into the activation of G proteins for downstream signaling. Figures - available via license: Creative Commons ...

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