胶质纤维酸性蛋白 （ Glail fibrillary acidicprotein,GFAP） 是一种 Ⅲ型中间纤维蛋白,主要存在于成熟的星形胶质细胞内,是星形胶质细胞的重要组成部分,也是主要的细胞骨架， 除了在神经系统星形胶质细胞内高量表达外， GFAP在软骨细胞、成纤维细胞、肌上皮细胞 ...

Increased expression of glial fibrillary acidic protein (GFAP) represents astroglial activation and gliosis during neurodegeneration. However, the molecular mechanism behind increased expression of GFAP in astrocytes is poorly understood. The present study was undertaken to explore the role of nitric oxide (NO) in the expression of GFAP.

2017年7月10日 · Glial fibrillary acidic protein (GFAP) is one of the best markers for the activation of astrocytes (AS) following injury or stress in the central nervous system (CNS). The purpose of this study was to examine the expression of GFAP and 14-3-3ε in rat AS subjected to hypoxia.

2014年5月1日 · Based on the transitional morphology of RG cells labeled by BLBP and GFAP over the first two postnatal weeks, we can infer that transformation of RG cells into astrocytes clearly is initiated by P2, and significant morphological changes occur between P2 and P7.

Glial fibrillary acidic protein (GFAP) was identified as the antigen, and one-third of cases were paraneoplastic. Meaning As a disease biomarker, GFAP-specific IgG unifies a spectrum of treatable autoimmune meningoencephalomyelitis, a new class of autoimmune astrocytopathy that is presumably mediated by GFAP peptide–specific cytotoxic CD8 + T ...

2024年8月10日 · SVZ 中的神经干细胞 （NSC） 具有某些关键特征：它们表达神经胶质纤维酸性蛋白 （GFAP），增殖缓慢，具有放射状胶质细胞样 （RG-L） 形态，并与脑脊液 （CSF） 接触。 FACS 已分离出 NSC 以分析它们，但尚未系统地检查它们的形态。 为了解决这一知识空白，我们通过在 GFAP 启动子的控制下通过电穿孔引入表达荧光蛋白的质粒，稀疏标记了新生小鼠 SVZ 中的 RG-L 细胞。 然后，我们根据 RG-L 细胞的形态将其分为三种类型 （RG-L1 、 2 和 3） …

Activated GFAP + /sox-2 + radial glial (RG)-like cells in peri-injured cortex. RG-like cells were detected by GFAP (green) and sox-2 (red) antibody. Arrows denote the GFAP + /sox-2 +...

2011年9月18日 · Human or rat-derived radial glia (RG)-like cells expressed GFAP in vitro, while the expression of GFAP in mouse-derived cells was negligible (Conti et al. 2005; Li et al. 2011). Several studies used a single astroglial marker to identified RGCs (Culican et al. 1990 ; Hartfuss et al. 2001 ; Hunter and Hatten 1995 ; Poluch and Juliano 2010 ...

For example, in primates, the intermediate filament proteins, glial fibrillary acidic protein (GFAP) and vimentin, are expressed concomitantly in RG from the initiation of neurogenesis at 5 to 6 gw in humans (Levitt and others 1981; Kadhim and others 1988; Cameron and Rakic 1991; Zecevic and others 1999; Zecevic 2004; Howard and others 2006).

2003年5月16日 · The GFAP-negative migrating neurons (blue) are distinguishable from the GFAP-positive RG cells (brown). RG fibers impregnated with Golgi method (F) and viewed with electron microscope. Adapted from Levitt and Rakic and Rakic .