The GH receptor (GHR) plays a key role in the the function of the GH/IGF-I axis and is the major effector of human growth. A common polymorphic variant consisting of genomic exon 3 deletion or retention (d3-GHR and full-length GHR, respectively), described in 2000, has been linked with increased rec …

2017年6月16日 · It appears that deletion of the GHR gene exon 3 might have originated from complex genomic events taking place after the emergence of Old World monkeys, followed by homologous recombination between two retro-elements in Homo sapiens. Thereafter, it spread throughout the human clades to be present now in approximately 25% …

Numerous investigations on the GHR exon 3 genotype in people with various syndromes, including children receiving hGH therapy, girls with Turner syndrome, children born small for gestational age, and patients with acromegaly, corroborated the beneficial effect of the d3GHR isoform on GH actions.

2014年3月27日 · The GH receptor (GHR) plays a key role in the the function of the GH/IGF-I axis and is the major effector of human growth. A common polymorphic variant consisting of genomic exon 3 deletion or retention (d3-GHR and full-length GHR, respectively), described in 2000, has been linked with increased receptor activity due to enhanced signal ...

2009年5月1日 · Growth Hormone Receptor Exon 3 Isoforms and Their Implication in Growth Disorders and Treatment. Human recombinant growth hormone (hGH) has been used to treat...

GH receptor (GHR) exon 3-deleted/full-length (d3/fl) polymorphism has been proposed to affect the responsiveness to GH therapy. Conventional multiplex PCR genotyping method for this polymorphism detection requires DNA samples, which may be difficult to obtain due to ethical and procedural issues and may limit further studies into the role of ...

2024年7月22日 · 本研究旨在了解矮小症儿童和正常儿童GHR基因外显子3缺失多态性的分布差异，为今后探讨其是否与矮小症的发病有关，并结合临床指标建立可靠的GH治疗预测模式奠定基础。 1.1 研究对象 自 2009年9月—2010年6月于天津医科大学总医院小儿内分泌科就诊的矮小症患儿中选出满足如下条件的143例作为试验组：（1）身高处于同年龄、同性别正常健康儿童生长曲线第3个百分位数以下或低于2个标准差（SD），符合矮身材标准。 （2）生长缓慢，生长速率<4 …

来自 JST Sales America Inc. 的 GHR-03V-S – 3 矩形连接器 - 外壳 插座 天然 0.049"（1.25mm）。 DigiKey 提供数以百万计电子元器件的定价和供应信息。

We report that the d3-GHR polymorphism has a significant effect on BMI and the metabolic parameters of Chinese children with obesity. The d3 allele may have a protective effect on the development of metabolic syndrome by increasing insulin sensitivity.

2023年9月10日 · 研究表明，d3GHR亚型对人类生长发育具有积极的促进作用，可提高受体活性和信号转导，从而改善GH/IGF-I轴的功能。 此外，d3GHR亚型还可能影响GH和IGF-I水平、身高、体重、BMI和其他变量之间的关系。 这些发现对于深入了解GH/IGF-I轴的生理和病理生理学，以及开发相关治疗方法具有重要意义。 本研究的创新点在于发现了GHR基因缺失可促进人类生长发育的机制，为GH/IGF-I轴的生理和病理生理学研究提供了新的思路。 这些发现还为开发相关治疗 …