2005年8月21日 · Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic...

Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor.

2016年10月12日 · GH receptor (GHR) antagonist therapy is more effective but requires frequent high-dose injections. We have developed an alternative technology for generating a long acting potent...

2020年12月1日 · In this review, I summarize historical and recent features of the classical pathways activated by growth hormone (GH) through the cell surface GH receptor (GHR). GHR is a cytokine receptor superfamily member that signals by activating the non-receptor tyrosine kinase, JAK2, and members of the Src family kinases.

Dysregulation of GHR signaling is associated with various diseases and chronic conditions such as acromegaly, cancer, aging, metabolic disease, fibroses, inflammation and autoimmunity. Numerous studies entailing the GHR signaling pathway have been conducted for various cancers.

co-administration of Ghr and GH is a promising therapeutic tool for reversing immunosuppression caused by sepsis in the geriatric population. Growth hormone receptor gene polymorphism is associated with scoliosis in Prader-Willi syndrome.

2024年11月13日 · Growth hormone-releasing hormone (GHRH) is a hypothalamic hypophysiotropic peptide that was discovered as a result of its ability to stimulate the synthesis and secretion of...

2023年9月15日 · 生长激素受体（growth hormone receptor, GHR）跨膜蛋白质，广泛存在于人体内各种细胞中。 它主要负责介导生长激素（GH）在目标细胞上的生物学效应，调节细胞生长、增殖和分化等生理过程。 GHR 可以通过配体结合和自身酪氨酸激酶活性的激活，促进细胞内的多种信号通路的启动，包括 JAK-STAT 、PI3K/Akt 和 Ras/MAPK 等信号通路，这些信号通路的激活将刺激多种信号转导与反应，并影响基因表达和细胞代谢。 当生长激素（GH）进入细胞后，会 …

GH binds the transmembrane GH receptor (GHR) to activate the intracellular GHR-associated tyrosine kinase, Janus kinase 2 (JAK2), and downstream signals, including signal transducer and activator of transcription 5 (STAT5) activation and IGF-1 gene expression.

2015年11月10日 · Growth hormone (GH) is a critical regulator of linear body growth during childhood but continues to have important metabolic actions throughout life. The GH receptor (GHR) is ubiquitously expressed, and deficiency of GHR signaling causes a dramatic impact on normal physiology during somatic development, adulthood, and aging.