2024年12月25日 · GLUD1 (Glutamate Dehydrogenase 1) is a Protein Coding gene. Diseases associated with GLUD1 include Hyperinsulinemic Hypoglycemia, Familial, 6 and Hyperinsulinemic Hypoglycemia, Familial, 7. Among its related pathways are GABA shunt and Glutamate and glutamine metabolism.

GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle.

2015年2月9日 · Our finding that GDH1 is upregulated in human cancers and that attenuation of GDH1 impacts cancer cell proliferation and tumor growth implicates GDH1 as a promising anticancer target. Currently, the only reported GDH1 inhibitor is epigallocatechin gallate (EGCG), a polyphenol flavonoid isolated from green tea.

gdh2与gdh1的不同之处在于，它对gtp抑制的敏感性较低，但对adp活化的敏感性更高，热稳定性低得多，并且活性比gdh1低。实际上，gdh2活性需要adp激活[ 22]。与gdh1一样[ 23]，gdh2主要定位于线粒体。

GLUD1 parental protein localizes to mitochondria and the cytoplasm, GLUD2 is specifically targeted to mitochondria. GLUD1 may have a role in hyperinsulinism/hyperammonaemia syndrome; Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations

2019年10月3日 · GDH1-produced α-KG directly binds to and activates IKKβ and nuclear factor κB (NF-κB) signaling, which promotes glucose uptake and tumor cell survival by upregulating GLUT1, thereby accelerating gliomagenesis. In addition, GDH1 S384 phosphorylation correlates with the malignancy and prognosis of human glioblastoma.

2024年6月17日 · This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP.

2025年2月8日 · GluD1 regulates the connectivity of parallel fiber-interneuron synapses and promotes differentiation of interneurons. The GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator.

该基因编码谷氨酸脱氢酶，它是一种线粒体基质酶，可催化谷氨酸氧化脱氨生成α-酮戊二酸和氨。 这种酶在调节氨基酸诱导的胰岛素分泌中具有重要作用。 它被 ADP 变构激活并被 GTP 和 ATP 抑制。 该基因的激活突变是先天性高胰岛素血症的常见原因。 该基因的可变剪接导致多个转录变体。 人类 X 染色体上的相关谷氨酸脱氢酶 2 基因通过逆转录起源于该基因，并编码可溶形式的谷氨酸脱氢酶。 已在 10 号、18 号和 X 号染色体上鉴定出相关的假基因。 [RefSeq 提供，2016 …

2015年2月9日 · Jin et al. show that mitochondrial glutaminolysis contributes to redox homeostasis through glutamate dehydrogenase 1 (GDH1) regulation of -ketoglutarate, fumarate, and GPx1. GDH1 is upregulated in human cancers, and its inhibition perturbs redox homeostasis and attenuates cancer cell proliferation and tumor growth.