2019年9月20日 · Fat and muscle cells contain a specialized, intracellular organelle known as the GLUT4 storage vesicle (GSV). Insulin stimulation mobilizes GSVs, so that these vesicles fuse at the cell surface and insert GLUT4 glucose transporters into the plasma membrane.

More than 90% of GLUT4 is located in the intracellular body, trans-Golgi network, and heterogeneous tube-like vesicle structure, etc., which constitute the GLUT4 storage vesicle (GSV). In an unstimulated state, most GLUT4 is in the intracellular vesicles of …

GLUT4 continuously recycles through several membrane systems of adipose and muscle cells and accumulates in sequestration vesicles (GSV) and perhaps other intracellular membranes (e.g., ERC, TGN) due to very slow exocytosis rates in the absence of stimulation.

2004年12月1日 · GLUT4 is retained in GLUT4 storage vesicles (GSVs) that dynamically recycle among many intracellular organelles, including the plasma membrane, sorting endosomes, recycling endosomes...

2012年5月23日 · In the absence of insulin, at least 50% of GLUT4 is sequestered in specialized immobile GSVs. Stimulation with insulin results in regulated exocytosis of GSVs. GSV mobilization, targeting and...

GLUT4 passes through recycling endosomes, the trans Golgi network and an insulin-sensitive intracellular compartment, termed GLUT4-storage vesicles or GSVs. It is from GSVs that GLUT4 is mobilized to the cell surface in response to insulin, where it …

2007年4月4日 · Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis. This review focuses on recent advances on the biology of GLUT4.

2015年9月25日 · In the absence of insulin, GLUT4 resides within specialized insulin-sensitive 50–70-nm storage vesicles (3, 4), termed GLUT4-storage vesicles (GSVs). These vesicles are distinct from the general endosomal recycling pathway, effectively sequestering GLUT4 and maintaining low levels of PM GLUT4 in the absence of insulin.

2011年4月19日 · Insulin-derived signals promote translocation of GLUT4 to the PM from a specialized compartment termed GLUT4 storage vesicles (GSV). Much effort has been devoted to the characterization of the intracellular compartments and dynamics of GLUT4 cycling and to the signals by which GLUT4 is sorted into, and recruited from, GSV.

Fat and muscle cells contain a specialized, intracellular organelle known as the GLUT4 storage vesicle (GSV). Insulin stimulation mobilizes GSVs, so that these vesicles fuse at the cell surface and insert GLUT4 glucose transporters into the plasma ...