2022年4月26日 · 当这些配体（gn/ugn/sta）与肠上皮细胞的gucy2c受体结合后，能激活gucy2c，使gucy2c受体具有鸟苷酸环化酶活性，从而发挥生物学效应。 此外，Gn、Ugn和STa在蛋白质序列和构象的差异，导致它们同GUCY2C受体结合的亲和力不同，激活GUCY2C受体的能力 …

2016年1月1日 · GN/UGN produced in intestinal epithelial cells is secreted into the lumen and/or into the circulation. Luminocrine GN/UGN binds to apically located GC-C, resulting in activation of Cl − and HCO 3 − secretion via CFTR and a non-CFTR type transport pathway, and in inhibition of Na + absorption via NHE3 1., 2.. The ion regulation eventually ...

Both peptides are produced and secreted from intestinal epithelial cells (IECs), with Ugn expressed predominantly in the small bowel and Gn in the colon. All three ligands (ST, Gn, and Ugn) bind the transmembrane receptor guanylate cyclase C (GC-C), which in the intestine is expressed only on IECs but can be found at low levels in ...

2016年4月29日 · Activation of GC-C via guanylin (Gn) and uroguanylin (Ugn) regulates intestinal fluid and electrolyte homeostasis. However, how it regulates the pathogenesis of inflammatory bowel disease (IBD)...

GC-C is also activated by bacterially-produced heat stable toxins (ST) such as STa(h), and STa(p), which are the causal agents for travelers’ diarrhea 7. In addition to their well-described actions within the intestine, Gn and Ugn circulate in plasma 8 – 12 and elicit natriuretic responses from the kidneys 13 – 15.

In this study we demonstrate for the first time cellular actions of GN, UGN, and STa in the human kidney, specifically a proximal tubule cell line. We propose two destinct receptors and signaling pathways for these peptides. GN, UGN, and STa inhibit a K + conductance via activation of GC-C and increases in cellular cGMP. The second receptor is ...

Some enterotoxigenic Escherichia coli (ETEC) produce heat-stable enterotoxin (ST), which induces diarrhea by mimicking GN and UGN. Plasma concentrations of prohormones of GN (proGN) and...

2023年8月3日 · The intestinal peptide hormones guanylin (GN) and uroguanylin (UGN) interact with the epithelial cell receptor guanylate cyclase C to regulate fluid homeostasis. Some enterotoxigenic Escherichia coli (ETEC) produce heat-stable enterotoxin (ST), which induces diarrhea by mimicking GN and UGN.

2004年1月1日 · Guanylin (GN) and uroguanylin (UGN) are intestinally derived peptide hormones that are similar in structure and activity to the diarrhea-causing Escherichia coli heat-stable enterotoxins (STa). These secretagogues have been shown to affect fluid, Na + , K + , and Cl − transport in both the intestine and kidney, presumably by intracellular ...

Guanylin (GN) and uroguanylin (UGN), through activation of guanylyl cyclase C (GCC), serve to control intestinal fluid homeostasis. Both peptides are produced in the intestinal epithelium, but their cellular origin has not been fully charted.