2024年4月10日 · G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface membrane receptors and are encoded by approximately 1000 genes, sharing conserved...

2024年12月25日 · GPR88 (G Protein-Coupled Receptor 88) is a Protein Coding gene. Diseases associated with GPR88 include Chorea, Childhood-Onset, With Psychomotor Retardation and Cortical Dysplasia, Complex, With Other Brain Malformations 13. Among its …

2022年5月2日 · GPR88 is an orphan class A G-protein-coupled receptor that is highly expressed in the striatum and regulates diverse brain and behavioral functions. Here we present...

GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and reward-based learning, and is thus emerging as a novel drug target for central nervous system disorders including schizophrenia, Parkinson’s disease, anxiety, and ad...

2022年6月2日 · MD和突变研究揭示了一组独特的结构特征和水介导的极性网络的GPR88的独特激活机制，为理解GPR88的配体结合、激活和信号传导机制提供了一个结构框架，并将促进神经精神疾病的创新药物发现以及该受体的“脱孤”。 香港中文大学（深圳）为第一作者单位，杜洋教授为该研究最后通讯作者。 陈耕博士、徐俊博士、Maximilian Schmidt和Asuka Inoue并列第一作者。...

G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface membrane receptors and are encoded by approximately 1000 genes, sharing conserved seven-transmembrane (7TM) helices connected by three intra- and three extra-cellular loops. 1–3 GPCRs are conformationally dynamic proteins that mediate vital biological functions of ...

g 蛋白偶联受体 88： 预计该基因编码的蛋白可实现 g 蛋白偶联光感受器活动和细胞骨架运动活动。 预计参与多个过程，包括细胞对光刺激的反应；运动学习；和光转导。

2024年4月10日 · In this study, we first review the structural advancements, activation mechanisms, and functional diversity of GPCRs. We then focus on GPCR drug discovery by revealing the detailed drug-target interactions and the underlying mechanisms of orthosteric drugs approved by the US Food and Drug Administration in the past five years.

腺苷 A1 受体拮抗剂，展示了靶向特定 GPCR 的方法。 作用于多种 GPCR 的非典型抗精神病药，体现了多靶点作用。 一种 Gi/o 型 G 蛋白抑制剂，可能会影响 GPCR 信号传导，包括 GPR 家族的 G 蛋白偶联受体。 一种 Gsα 亚基抑制剂，间接影响 GPCR 信号通路。

2020年1月31日 · GPR88 is an orphan GPCR (its endogenous ligand is not known) mainly expressed in the striatum and already shown to play important roles in brain physiology. The authors previously characterized the GPR88 knockout mice and show that the functional responses of the M1 muscarinic, mu and delta opioid receptors were potentiated.