2024年4月10日 · G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface membrane receptors and are encoded by approximately 1000 genes, sharing...

2025年2月27日 · G protein-coupled receptors (GPCRs) constitute a functionally diverse protein family and are targets for a broad spectrum of pharmaceuticals. Technological progress in...

2021年1月8日 · As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.

g蛋白偶联受体（gpcr）是真核生物中最大的细胞表面受体组。gpcr就像一个“收件箱”，可以接收细胞外的光能、肽、脂质、糖和蛋白质等不同形式的信号，让细胞知道环境中是否存在维持生长的物质，或者将信息传导给其…

2024年4月19日 · G protein-coupled receptors (GPCRs) located at the cell surface bind extracellular ligands and convey intracellular signals via activation of heterotrimeric G proteins.

2024年11月11日 · G-protein-coupled receptors (GPCRs) initiate classical G-protein-mediated signaling on membranes of intracellular organelles, such as endosomes or the Golgi. A growing number of GPCRs have been shown to initiate endomembrane G-protein-mediated signaling.

G protein–coupled receptors (GPCRs) are essential mediators of signal transduction, neurotransmission, ion channel regulation, and other cellular events. GPCRs are activated by diverse stimuli, including light, enzymatic processing of their N-termini, and binding of proteins, peptides, or small molecules such as neurotransmitters.

2024年6月20日 · GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with ≈800 members. GPCRs regulate nearly every aspect of human physiology and disease, thus serving as important drug targets in cardiovascular disease.

2025年2月15日 · This review focuses on six GPCRs, GPR40, GPR120, GLP-1R, and ß-adrenergic receptors (ADRB1, ADRB2, and ADRB3), with GLP-1R recognized as a prominent regulator of system-level metabolism, while the roles of GPR40, GPR120 and ß-adrenergic receptors in central carbon metabolism and energy homeostasis are increasingly appreciated.

G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins that are involved in regulation of sensory and physiological processes and implicated in many diseases. The last decade revolutionized the GPCR field by unraveling multiple high-resolution structures of many …