Hydroxycarboxylic acid receptor 2 (HCA 2), also known as GPR109A and niacin receptor 1 (NIACR1), is a protein which in humans is encoded (its formation is directed) by the HCAR2 …

GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.

2009年4月1日 · The expression of GPR109A is silenced in colon cancer in humans, in a mouse model of intestinal/colon cancer, and in colon cancer cell lines. The tumor-associated silencing …

GPR109A, a Gi protein-coupled receptor, has emerged as an important therapeutic target for controlling inflammation in various tissues and organs. In this review, we summarized current …

2021年1月8日 · GPR109A deletion led to suppressed Wnt/β-catenin signaling in osteoclast precursors to inhibit osteoclast differentiation and activity.

2014年1月16日 · GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses …

The importance of the microbiota in Gpr109a-mediated protective effect is clearly demonstrated in antibiotic-treated WT mice, which displayed enhanced AOM+DSS-induced tumorigenesis …

2014年2月16日 · GPR109A, a G-protein–coupled receptor, is activated by niacin and butyrate. Upon activation in colonocytes, GPR109A potentiates anti-inflammatory pathways, induces …

2009年11月1日 · The discovery of GPR109A as a receptor for the antidyslipidemic drug nicotinic acid has included this receptor and its relatives GPR109B and GPR81 as part of many …

GPR109A was demonstrated to be responsible for the antilipolytic and triglyceride-lowering effects of nicotinic acid as well as for the major side effects of nicotinic acid, a cutaneous …