Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. [5] This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. [6]

2024年12月25日 · GPX1 (Glutathione Peroxidase 1) is a Protein Coding gene. Diseases associated with GPX1 include Glutathione Peroxidase Deficiency and Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency.

该基因编码的蛋白质属于谷胱甘肽过氧化物酶家族，其成员催化谷胱甘肽还原有机氢过氧化物和过氧化氢 (H2O2) ，从而保护细胞免受氧化损伤。 其他研究表明，H2O2 对于生长因子介导的信号转导、线粒体功能和硫醇氧化还原平衡的维持也是必不可少的；因此，通过限制 H2O2 的积累，谷胱甘肽过氧化物酶也参与调节这些过程。 该基因家族的几种同工酶存在于脊椎动物中，它们在细胞位置和底物特异性方面有所不同。 这种同工酶是最丰富的，普遍表达并定位于细胞质中，其首 …

谷胱甘肽过氧化物酶（Glutathione peroxidase，GSH-Px）是机体内广泛存在的一种重要的过氧化物分解酶。 GSH-Px的活性中心是硒半胱氨酸，其活力大小可以反映机体硒水平。 硒是GSH-Px酶系的组成成分，它能催化GSH变为GSSG，使有毒的过氧化物还原成无毒的羟基化合物，从而保护细胞膜的结构及功能不受过氧化物的干扰及损害。 NADPH的减少量则和谷胱甘肽过氧化物酶的活力线性相关。 GSH-Px主要包括4种：分别为胞浆GSH-Px、血浆GSH-Px、磷脂氢过氧化 …

2022年5月23日 · GPX1可参与多种信号通路调控肿瘤生物学行为，包括细胞增殖、凋亡、侵袭、免疫反应和化疗耐药等。 在这篇综述中，我们全面总结了 GPX1 多态性与癌症风险之间存在争议的关联，并进一步讨论了 GPX1 的异常表达与肿瘤发生之间的关系。 需要进一步的研究来阐明 GPX1 作为各种恶性肿瘤的潜在预后生物标志物和新治疗靶点的临床意义。 GPX1可参与多种信号通路调控肿瘤生物学行为，包括细胞增殖、凋亡、侵袭、免疫反应和化疗耐药等。 在这篇综述中， …

2025年2月8日 · Title: Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma. Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis.

Glutathione peroxidase 1 (GPx1) is the most abundant version, found in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in nearly every mammalian cell, though at much lower levels.

GPX1 overexpression blocks cisplatin-induced ROS intracellular accumulation, activates PI3K-AKT pathway by increased AKT phosphorylation, and further leads to cisplatin resistance in NSCLC cells. GPX1 Pro198Leu (Pro/Leu or Leu/Leu) polymorphism was associated with reactive gastropathy changes in gastric biopsies and less severe endoscopic lesions.

We review the role of GPx1 in cardiovascular and metabolic health, provide examples of how GPx1 modulates stroke and provides neuroprotection, and consider how GPx1 may contribute to cancer risk.

2022年7月1日 · Glutathione peroxidase (GPx1) was the first mammalian selenoprotein to be discovered. The glutathione peroxidases (GPxs) grew up to a highly diversified family of proteins. GPxs catalyze the reduction of hydroperoxides by different thiols. Hydroperoxide reduction is achieved by oxidation of a selenocysteine or cysteine.