2005年12月9日 · G protein–coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein–coupled receptor signaling by phosphorylating activated …

2024年7月3日 · G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed …

2023年8月2日 · Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gαq and the arrestin-biased ligand SBI-553 provide …

GRK2 and Gbg. This interaction not only stimulates tran-sient translocation of GRK2 to the membrane [36,37], but also leads to desensitization of the G protein-coupled in-wardly …

最近发现, 激动剂刺激哺乳动物细胞 (HEK293)后, 能够诱导GPCR、GRK2和Gbg在细胞膜上形成稳定的复合体, 激动剂诱导的受体-GRK2-Gbg复合体的形成是 GRK2向细胞膜转位和GRK2发挥 …

Recently, the X-ray crystal structure of GRK2 complexed with Gbg was demonstrated and revealed the intimate association of three important signaling modules with Gbg to regu-late …

2005年7月15日 · We report the atomic structure of GRK2 in complex with Ga q and Gbg,in which the activated Ga subunit of G q is fully dissociated from Gbg and dramat-ically reoriented from …

This domain glycine-rich β-globulin (Gbg) plays a role in targeting and translocation of these primarily cytosolic GRKs to membranes following GPCR activation. More recently, a second …

Ligand binding to CXCR7 does not result in activation of typical signaling pathways via Gα subunits but activation of GRK2 via βγ subunits and receptor phosphorylation with subsequent …

2005年12月9日 · G protein-coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein-coupled receptor signaling by phosphorylating activated …