2020年9月28日 · These data suggest that GRK2 inhibits HCC metastasis and invasion may be through regulating EP2 receptor translocation, and this effect appears to be mediated by Akt …

2020年9月28日 · We found that GRK2 expression was significantly decreased in HCC tissues compared with noncancerous tissues of HCC patients, while GRK3 expression was not …

Our data indicate that the anti-proliferative function of elevated GRK2 is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent. Enforced expression of GRK2 …

In this study, we investigated a novel approach for HCC treatment by inducing overexpression of GRK2 in human HCC cells. We found that overexpression of GRK2 through recombinant …

2023年8月21日 · 环状RNA ( circular RNA，circRNA )对HCC肿瘤黏附和侵袭的调控作用，是多种细胞过程的重要调节因子，并与癌症进展密切相关。 2023年7月17日，浙江大学蔡秀军及史亮 …

2018年6月19日 · By inducing the overexpression of GRK2 through recombinant adenovirus transduction in human HCC cells, cell proliferation and apoptosis are investigated. These data …

2019年7月11日 · G protein-coupled receptor kinase 2 (GRK2) can regulate G protein-coupled receptor (GPCR). Previous studies showed that down-regulation of GRK2 in HCC contributes …

2017年3月18日 · GRK2 has a variety of different physiological and pathological functions, while its activity and expression can be regulated by many factors. It is reported that GRK2 can …

In this study we found that GRK2 plays an inhibitory role in IGF1-induced HCC cell proliferation and migration. Overexpression of GRK2 causes a decrease in early growth response-1 …

In this review, we discuss traditional and newly discovered roles of GRK2 in receptor internalization and signaling as well as its impact on non-receptor substrates. We also discuss …