The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein. [5][6][7] L - Glutamate is the major …

2024年12月25日 · GRM1 (Glutamate Metabotropic Receptor 1) is a Protein Coding gene. Diseases associated with GRM1 include Spinocerebellar Ataxia, Autosomal Recessive 13 and …

与人类 GRM1（谷氨酸代谢受体 1）直系同源。 [由基因组资源联盟提供，2022 年 4 月] Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic …

we report the third pathogenic variant in GRM1 gene causing an autosomal-recessive form of cerebellar ataxia. Our observation not only emphasizes the central role of mGluR1-mediated …

we report the third pathogenic variant in GRM1 gene causing an autosomal-recessive form of cerebellar ataxia. Our observation not only emphasizes the central role of mGluR1-mediated …

2012年10月22日 · We hypothesize that inappropriate glutamatergic signaling in other cell types can dysregulate growth leading to transformation and tumorigenesis. As most cancers are …

2024年9月12日 · Clinical resource with information about GRM1, Autosomal recessive spinocerebellar ataxia 13, Spinocerebellar ataxia 44, and available tests. There are links to …

Activation of GRM1 results in the release of glutamate from neurons and melanoma cells, setting up paracrine feedback loops that enhance GRM1-activation and signal transduction (9, 14). In …

该基因编码一种代谢型谷氨酸受体，该受体通过激活磷脂酶 C 发挥作用。 L-谷氨酸是中枢神经系统中主要的兴奋性神经递质，可激活离子型和代谢型谷氨酸受体。 谷氨酸能神经传递涉及正常 …

Our findings unequivocally demonstrate that direct targeting of GRM1 is a necessary and highly specific driver event for CMF development. Glutamate receptors are well-known actors in the …