2022年7月11日 · S 6 phosphorylation stabilizes Siah2 and P-S 6 -Siah2 potentiates H. pylori-mediated reactive oxygen species (ROS) generation. However, infected S6A phospho-null Siah2-expressing cells have decreased cellular GRP78 level as surprisingly these cells release GRP78 to a higher extent and accumulate significantly higher ROS than the wild type (WT ...

2019年2月12日 · Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells...

2024年7月1日 · Mechanistically, GRP78 plays a crucial role in defending against reactive oxygen species (ROS) production and the heightened ER stress observed in EGFR-TKI-resistant cells. Blockade of GRP78 resulted in a reduction of tumor growth in a …

Silencing GRP78 with both siGRP78–1 and siGRP78–2 was shown to increase ROS levels, and downregulate SOD2 and CAT expression in three lines (Fig. 8D, E). In agreement with above-mentioned results, both GRP78-silenced prostatic epithelial cells (BPH-1 and RWPE-1) displayed a downregulation of E-cad, N-cad and vimentin, concomitant with an ...

Our results indicate that epirubicin decreased the intracellular ROS in GRP78 knockdown cells, which decreased survival signaling through both the Akt pathway and the activation of PP2A. Together, these mechanisms contributed to the enhanced level of epirubicin-induced apoptosis that was observed in the GRP78 knockdown cells.

GRP78/BiP is a major endoplasmic reticulum (ER) chaperone protein critical for protein quality control of the ER, as well as controlling the activation of the ER-transmembrane signaling molecules. Through creation of mouse models targeting the Grp78 allele, the function of GRP78 in development and disease has been investigated.

2005年3月1日 · GRP78 depletion significantly increased the sensitivity of cells to Pb exposure as indicated by the generation of reactive oxygen species (ROS). These data suggest that Pb directly targets GRP78 and induces its compartmentalized redistribution in living cells and that GRP78 plays a protective role in Pb neurotoxicity.

2022年4月1日 · ROS is the key mediator of podocyte injury induced by upregulation of Angptl3 in LPS-treated podocytes. Angptl3 induces podocyte apoptosis through ROS/GRP78 signaling pathway. Acute kidney injury (AKI) caused by sepsis has a high incidence and poor prognosis. Thus, novel strategies that minimize AKI are urgently needed.

RPE cells exhibited ROS accumulation and subsequent elevation of GRP78 and CHOP expression after A2E and blue light-induced damage. The ROS scavenger NAC diminished ER stress protein expression, suggesting a connection between ER and oxidative stress in blue light-mediated damage of A2E-containing R …

Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs)...