2020年3月20日 · Our results suggested that inhibition of the ERK pathway may promote OC differentiation via upregulation of GSH. These findings reveal that ERK and GSH modulate the signal pathway necessary for OC differentiation, and this may form the basis of a new therapeutic strategy for treating OC-related diseases.

2024年7月1日 · Re-educating TAMs to M1-like by regulating ERK/MAPK via HBEGF. This nanosystem generates robust antitumor effect via chemo-immunotherapy. The low targeting of immunity regulators & chemotherapy drugs and immune tolerance in the tumor microenvironment significantly hindered the chemo-immunotherapy effect.

我们的结果表明抑制 erk 通路可能促进 oc 分化通过上调 gsh。这些发现表明 erk 和 gsh 调节了 oc 分化所必需的信号通路，这可能构成治疗 oc 相关疾病的新治疗策略的基础。

2024年1月1日 · These results suggest that RA protects against UVB-induced oxidative damage by activating AKT and ERK signaling to regulate NRF2 signaling and enhance GSH biosynthesis. Thus, RA treatment may be a promising approach to …

2003年12月1日 · Intracellular glutathione (GSH) levels determine whether nitric oxide (NO) is neurotrophic for dopamine neurons or triggers a cell death cascade in primary midbrain cultures. We have investigated herein the role of the extracellular-signal regulated protein kinase (ERK) 1/2 pathway in this GSH switching effect.

2018年6月13日 · 酶促和非酶促抗氧化剂，例如丙二醛（mda），超氧化物歧化酶（sod），用分光光度法测量过氧化氢酶（cat）和谷胱甘肽（gsh）。 还通过蛋白质印迹分析测量了热休克蛋白（HSP70和HSP90），与HSPs相关的信号分子（Akt，ERK，胞质和核NFkB）以及褪黑激素受体 …

2020年7月17日 · The mitogen-activated protein kinase (MAPK)/extracellular signal kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signal transduction pathways have been implicated in the pathogenesis of leukemia. The aim of this study was to investigate the effect of the combination of E …

2023年11月15日 · Moreover, MC-LR exposure induced a notable elevation of p-ERK levels both in vivo and in vitro. Furthermore, treatment with an ERK inhibitor partially restored cell viability, the GSH/GSSH ratio, and enhanced Gpx4 and Slc7a11 protein levels, along with a reduction in ROS levels in BV-2, HT-22 and bEnd.3 cells.

在这项研究中，我们研究了高良姜素对参与还原型谷胱甘肽 (GSH) 合成的抗氧化酶的诱导作用，并研究了相关的上游信号级联。 通过激活核因子-红细胞 2 相关因子 (Nrf2)，高良姜素处理显着增加了谷氨酸-半胱氨酸连接酶催化亚基 (GCLC) 和谷胱甘肽合成酶 (GSS) 的表达。 Nrf2 的这种激活取决于细胞外信号调节激酶 (ERK) 和蛋白激酶 B (AKT) 信号。 在高良姜素处理的细胞中抑制 GSH 减弱了高良姜素对 UVB 有害作用的保护作用。 以前，我们证明高良姜素（3,5,7-三羟基黄酮） …

We present herein crystal structures of human LanCl1 bound to methyl GSH (1.58 Å resolution) or to the product of GSH addition to a Dhb-containing peptide that mimics the activation loop of Erk (1.91 Å resolution).