
Imbalanced GSH/ROS and sequential cell death - PubMed
Imbalanced ROS/GSH may result from a direct increase of ROS, consumption of GSH, intracellular oxidoreductase interference, or thioredoxin activity reduction. Some chemicals …
Application of glutathione depletion in cancer therapy: Enhanced ROS ...
2021年10月1日 · GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), …
脂质过氧化和铁代谢:铁死亡稳态控制的两个基石。,International …
2022年12月27日 · The main mechanism that reduces ROS is the redox ability of glutathione (GSH). GSH, a tripeptide that includes glutamic acid, cysteine, and glycine, acts as an …
铁死亡检测指标 - 知乎
谷胱甘肽(GSH)是细胞内最丰富的抗氧化剂,可以在谷胱甘肽过氧化物酶4(GPX4)的催化下清除细胞内的 活性氧 (ROS)。 使用GSH检测试剂盒在酶标仪或生化分析仪上检测细胞或组织 …
谷胱甘肽耗竭在癌症治疗中的应用:基于活性氧的增强疗法、铁死 …
In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. …
脂质体:靶向、GSH和ROS响应的三重“杀手” - DXY.cn
2023年7月13日 · 这种脂质体可以实现靶向、GSH和ROS响应的三重“杀手”效果,有效地杀死肿瘤细胞,同时减少对正常组织的损伤。 这种脂质体是一种创新的抗癌药物平台,为癌症治疗带 …
Glutathione system enhancement for cardiac protection ... - Nature
2023年2月16日 · The GSH system is one of the most significant members of the cellular antioxidant defensive system, which is essential for eliminating excess ROS and protecting the …
3篇Cancer Res文章均锁定同一通路!谷胱甘肽代谢通路这么火?
谷胱甘肽(GSH)是细胞中表达最为丰富的一种抗氧化剂,正常情况下SLC7A11输出大量细胞内的谷氨酸,以换取细胞外的胱氨酸,SLC7A11导入的胱氨酸则转化为半胱氨酸,支持谷胱甘肽 …
Role of glutathione depletion and reactive oxygen species
2002年2月25日 · After BSO treatment, there was an early decline in cellular glutathione (GSH), followed by an increase in reactive oxygen species (ROS) production, which induced a variety …
肿瘤能量代谢调控的关键转录因子|STAT3|STAT5|ROS|糖酵解|线粒 …
2023年7月21日 · STAT3 高水平的ROS通过pJAK3-STAT介导肿瘤细胞的抗凋亡作用。 STAT3对谷胱甘肽(GSH)的合成至关重要,阻断STAT3会大幅度降低GSH而增加ROS的水平,导致 …
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