Glyceryl trinitrate (GTN) is a frequently used drug for patients with cardiovascular problems. In Australia, nurses may give GTN without direction from a medical officer if the health care facility has a treatment algorithm relevant to a patient complaint of chest pain.

GTN bioactivation in vascular smooth muscle is required to promote effective vasorelaxation treatment of angina pectoris and congestive heart failure. However, the usefulness of GTN is widely limited by the development of tolerance to the drug.

2018年4月17日 · Organic nitrates, such as glyceryl trinitrate (GTN), are a highly effective means of rapidly delivering nitrate and nitrite into the blood stream, and are potent vasodilators. The transdermal GTN patch is widely used to reduce angina in patients with acute and chronic ischaemic syndromes due to coronary artery disease.

2022年3月14日 · Although certain therapies such as early invasive therapy, dual antiplatelet therapy, and angiotensin-converting enzyme inhibition have clear prognostic benefits, use of sublingual glyceryl trinitrate therapy (GTN) after discharge appears to …

GTN is one of the most commonly used cardiovascular drugs. In this study, we have used in vivo 31 P magnetic resonance spectroscopy to assess human ATP kinetics during GTN infusion. We have shown that despite its hemodynamic effect of reducing mean arterial pressure and cardiac work, ATP delivery through CK is increased; however, GTN ...

2021年12月31日 · As such we sought to measure whether myocardial energetics were impaired during glyceryl trinitrate (GTN) infusion. Methods: 10 healthy volunteers underwent cardiac magnetic resonance imaging to assess cardiac function and 31 phosphorus magnetic resonance spectroscopy to measure Phosphocreatine/ATP (PCr/ATP) ratio and creatine kinase forward ...

Objective: To determine how the vasodilator glyceryl trinitrate (GTN) alters arterial stiffness and improves left ventricular afterload. Methods: Ascending aortic pressure waves were measured with fluid filled catheters of high fidelity in 50 patients undergoing cardiac surgery, before cardiopulmonary bypass, both before and after intravenous ...

Background Sublingual nitroglycerin (glyceryltrinitrate, GTN) capsules or isosorbide dinitrate (ISDN) spray are routinely used to treat anginal attacks and to vasodilate maximally the epicardial coronary arteries during coronary angiography.

2018年4月17日 · The glyceryl trinitrate (GTN) patch is commonly used as a simple and practical means of delivering nitric oxide to patients with ischaemic heart disease, but whether acute cardioprotection can be achieved by application of a GTN patch has not been investigated before.

2021年12月31日 · Conclusion: During GTN infusion, despite reduced LV stroke work and maintained cardiac output, there was a 44% increase in myocardial ATP delivery through CK. As PCr/ATP fell, this increase in...