GVAX is a cancer vaccine composed of whole tumor cells genetically modified to secrete the immune stimulatory cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), …

GVAX is a granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transfected tumor cell vaccine. Original work with GM-CSF as a recombinant DNA protein (Leukine) involved …

Colon GVAX is an allogeneic, whole‐cell, granulocyte‐macrophage colony‐stimulating factor‐secreting cellular immunotherapy that induces T‐cell immunity against tumor‐associated …

2021年8月2日 · Vaccination using irradiated, GM-CSF producing tumor cells (GVAX) consistently induced antitumor immunity across several experimental tumor models.

GVAX® is an investigational allogeneic cancer vaccine platform based on the local production of granulocyte-macrophage colony stimulating factor (GM-CSF) at the vaccine site to generate a …

2023年5月31日 · GVAX is an allogenic, whole cell, GM-CSF-secreting vaccine that activates T-cell immunity against tumor-associated antigens. Prior work has shown that GVAX in …

2019年2月8日 · The GVAX vaccines are composed of whole tumor cells genetically modified to secrete the immune stimulatory cytokine, granulocyte-macrophage colony-stimulating factor …

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic pancreatic tumor cell (GVAX) immunotherapy consists of two irradiated human allogeneic pancreatic …

Prostate cancer is among the diseases where a large amount of promising data has been accumulating regarding several distinct active immunotherapies. Here the authors review one …

2014年7月21日 · GVAX is made from irradiated pancreatic cell lines that secrete GM-CSF. Low-dose cyclophosphamide is administered prior to GVAX, to prevent regulatory T cells from …