2024年12月25日 · GAB1 (GRB2 Associated Binding Protein 1) is a Protein Coding gene. Diseases associated with GAB1 include Deafness, Autosomal Recessive 26 and Glioblastoma. Among its related pathways are Downstream signaling of activated FGFR2 and Insulin receptor signalling cascade.

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. [5] The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein …

2016年10月9日 · Role of GRB2-associated binder 1 in epidermal growth factor receptor-induced signaling in head and neck squamous cell carcinoma. Hoeben A, et al. Int J Cancer, 2013 Mar 1.

iated binder family proteins) 是生长因子受体结合蛋�. 2 的结合蛋白。在哺乳动物中,Gab家族蛋白包括Gab1、Gab2 和Gab3。该家族蛋白可通过介导膜受体与信号转导蛋白间的耦联及各信号分子间的相互作用参与信号转导,其主要是通过激活SHP2/RAS/ ERK 和PI3K/AKT 两条经典的信号通路,进而参与一系列的生物应答。研究显示,Gab蛋白的表达�. 功能异常与肿瘤、炎症和心血管疾病的发生、发展密切相关。本文就Gab蛋白结构、参与信号转导的调节机制 .

2023年8月20日 · GRB2-associated binder 1 (GAB1) is a docking protein pivotal in linking multiple stimuli to various intracellular signaling pathways. Embryonic development is disrupted in GAB1-deficient mice, and oncogenic mutations have been noted in cancer cases. In numerous types of cancer, high GAB1 expression levels correlate with a poor prognosis.

2019年10月24日 · Grb2-associated binder (Gab) family proteins are multi-site docking proteins, which expand cytokine-induced signal transduction in a spatial- and time-dependent manner by coordinating the recruitment of proteins involved in mitogen activated protein kinase (MAPK)/extracellular-signal regulated kinase (ERK) and phosphatidyl-inositol-3-kinase ...

2025年2月8日 · Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells. Data show that guanine nucleotide-binding protein G (i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.

2012年7月2日 · Grb2-associated binder 1 (Gab1) is a docking protein that transduces signals from a variety of tyrosine kinases, including Met and the epidermal growth factor receptor (EGFR)....

2000年6月26日 · Gab1 is a substrate of the receptor tyrosine kinase c-Met and involved in c-Met-specific branching morphogenesis. It associates directly with c-Met via the c-Met-binding domain, which is not related to known phosphotyrosine-binding domains. In addition, Gab1 is engaged in a constitutive complex with the adaptor protein Grb2.

2006年7月7日 · Grb2-associated binder 1 (GAB1) is a scaffold protein involved in numerous interactions that propagate signaling by growth factor and cytokine receptors. Here we explore in silico and validate in vivo the role of GAB1 in the control of mitogenic (Ras/MAPK) and survival (PI3K/Akt) signaling stimulated by epidermal growth factor (EGF).