GABA is catabolized in the mitochondrial matrix through the GABA shunt, encompassing transamination to succinic semialdehyde followed by oxidation to succinate by the concerted …

GABA is degraded to succinate by GABA-T and SSADH in two steps. The first catabolic step involves the transfer of GABA to α-KG by transamination, which results in the formation of …

2013年3月24日 · Glutamine-dependent anerplerosis is the principal source of succinate, although the ‘GABA (γ-aminobutyric acid) shunt’ pathway also has a role. Lipopolysaccharide-induced …

2018年1月1日 · In general, GABA is mainly catabolized into succinate by GABA-T and SSADH which then moves to TCA cycle for further metabolism. In plants, SSA can be catabolized to …

11 小时之前 · A notably mild phenotype of the Δssadh mutant suggests that the GABA-derived succinic semialdehyde is not a significant contributor of succinate. Similarly, loss of GABA-AT, …

2023年7月26日 · After uptake, intracellular GABA is converted to succinate by the GABA-degrading enzymes GABA transaminase (GABA-T) and succinic semialdehyde …

2018年11月7日 · Succinic semialdehyde dehydrogenase (SSADH) expression was correlated to GABA oxidation. GABA addition to glioma cells increased proliferation rates. Expression of …

In GABAergic neurons one half enters the mitochondria, whereas the other one half is released directly from the cytosol. A revised concept is proposed for the synthesis and metabolism of …

2016年11月25日 · The suggested glutamate-GABA exchange at the mitochondrial membrane has not been described in mammalian brain, but metabolism of GABA via succinic semialdehyde …

GABA is converted to succinate in a two‐step sequence catalyzed by GABA‐transaminase (GABA‐T; generating succinic semialdehyde (SSA)) and succinic semialdehyde …