
GALNT4 Gene - GeneCards | GALT4 Protein | GALT4 Antibody
2024年12月25日 · GALNT4 (Polypeptide N-Acetylgalactosaminyltransferase 4) is a Protein Coding gene. Diseases associated with GALNT4 include Childhood-Onset Schizophrenia and Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Metabolism of proteins and O-linked glycosylation of mucins.
Role of GALNT4 in protecting against cardiac hypertrophy
2021年10月22日 · In summary, GALNT4 may serve as a new regulatory factor and therapeutic target by blocking the activation of the ASK1 signaling cascade. Cardiac hypertrophy can accelerate the process of heart...
GALNT4 primes monocytes adhesion and transmigration by
Functional investigations demonstrate that GALNT4 knockdown inhibited P-selectin-induced activation of β2 integrin on the surface of monocytes, decreased monocytes adhesion under flow condition with P-selectin stimulation, as well as suppressed monocytes transmigration triggered by monocyte chemotactic protein- 1(MCP-1).
ESC中国之声丨黄榕翀教授:GALNT4通过调节ACS患者PSGL-1的O …
2021年8月29日 · 进一步细胞机制发现,galnt4可通过影响akt/mtor途径影响单核细胞的粘附、迁移功能,当加入mtor抑制剂-雷帕霉素后可部分抑制galnt4上调引起的活化单核细胞作用。
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4
GALNT4 identified as a risk gene for cardiovascular disease, whose effects may be on either platelet or endothelial function through modifications of PSGL1 or other important glycosylated proteins. Observational study of gene-disease association.
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4
2024年12月10日 · Clinical resource with information about GALNT4, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.
N-Acetylgalactosaminyltransferase 4 (GALNT4) | 糖基转移酶 | MCE
N-Acetylgalactosaminyltransferase 4 (GALNT4) 是一种能够抑制 ASK1 激活的糖基转移酶。 N-Acetylgalactosaminyltransferase 4 通过直接结合ASK1,抑制其 N 端二聚化和随后的磷酸化,从而导致下游JNK/p38和 NF-κB 信号的强烈失活,进而改善肝脏手术的预后。
GALNT4基因详情-基因数据库-基因云馆 - Genelibs
GALNT4的详细信息,包括基因名称,代码,染色体位置,相互作用关系和通路,简述为此基因编码UDP-N-乙酰基的α-D-半乳糖胺的成员:多肽N-二acetylgalactosaminyltransferase胺(GalNAc-T)的酶家族。
Role of GALNT4 in protecting against cardiac hypertrophy
2021年10月22日 · Pathological myocardial hypertrophy is regulated by multiple pathways. However, its underlying pathogenesis has not been fully explored. The goal of this work was to elucidate the function of polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) in myocardial hypertrophy and its underlying mechan …
GALNT4 primes monocytes adhesion and transmigration by regulating …
2022年4月1日 · Genome wide association studies have predicted that GalNAc-T4 (GALNT4), which responsible for initiating step of mucin-type O-glycosylation, plays a causal role in the susceptibility to cardiovascular diseases, whereas the precise mechanism remains obscure. Thus, we sought to determine the role and mechanism of GALNT4 in atherosclerosis.