2025年1月16日 · By building synthetic regulatory landscapes, Jensen et al. 1 and Thomas et al. 2 demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.

2025年1月16日 · These experiments demonstrate that synergy between enhancers depends on both the individual enhancer activities and the relative genomic distances between the enhancers and the gene promoter.

Enhancers are a class of regulatory elements essential for precise spatio-temporal control of gene expression during development and in terminally differentiated cells. This review highlights signature features of enhancer elements as well as new ...

增强子(enhancer)，是DNA上一段可与蛋白质（反式作用因子，trans-acting factor）结合的区域，可以被转录因子等蛋白结合从而激活基因转录。 1981年，增强子首次被描述为猿猴病毒40 (SV40)基因组中一个72bp的重复序列，可以使报告基因的异位表达增加约200倍。

By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of that gene expression levels strongly depend on the genomic distance between enhancers Molecular Cell and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.

2017年9月5日 · 通过利用CRISPR/Cas9敲除enhancer，作者发现enhancer的缺失能够特异性的阻止附近基因上暂停RNAPII的释放，而对暂停RNAPII的形成没有显著影响 （ 图3C ） 。这说明了PAF1通过抑制enhancer的活性来减弱附近基因上暂停RNAPII的释放；而暂停RNAII的形成主要依赖于promoter本身的 ...

By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of Molecular Cell that gene expression levels strongly depend on the genomic distance between enhancers and promoters and that enhancer cooperation can compensate for reduced enhancer activity over large genomic distances.

Here we present evidence that every gap gene contains multiple enhancers with overlapping activities to produce authentic patterns of gene expression. For example, a recently identi ed ( ) enhancer (located fi hunchback hb 5-kb upstream of the classic enhancer) ensures repression at the anterior pole.

2025年1月16日 · Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes

2012年9月13日 · Increasing gap junction activity in tumor cells provides the targets to enhance antineoplastic therapies. Previously, a new class of substituted quinolines (PQs) acts as gap junction enhancer, ability to increase the gap junctional intercellular communication, in …