2022年3月16日 · GARP是一种I型跨膜细胞表面对接蛋白，用于潜伏性转化生长因子-β1（TGF-β1）在活化的调节性T淋巴细胞、活化的B细胞和血小板上的表达。 GARP调节TGF-β1的定位 …

HLX-60是一款GARP单抗，可阻断TGF-β1的释放，从而减小TGF-β1的免疫抑制作用；同时，还可以引发ADCC效应，清除GARP+ Treg。 2022年8月26日，HLX-60与PD-1单抗联用于实体瘤 …

2020年9月11日 · In human melanoma samples infiltrated by T cells and GARP-expressing Tregs, we found evidence of TGF-β signaling within the T cell compartment, suggesting that blockade …

Two anti-GARP monoclonal antibodies recognize a conformational epitope within GARP-mTGF-β complex and block the production of active TGF-β from human Tregs. The two antibodies can …

Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however, whether GARP …

Membrane localization of latent TGF-beta mediated by binding to GARP may be necessary for the ability of Treg to activate TGF-beta upon TCR stimulation. However, it is not sufficient as …

2018年2月20日 · GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly …

2022年7月7日 · GARP, a transmembrane protein, is the docking receptor for latent transforming growth factor (LTGF-β) and thereby plays a critical role in the production and release of active …

2017年9月26日 · More recently, the protein GARP was shown to be involved in TGF-β1 activation by regulatory T cells (Treg), a subset of CD4 + T lymphocytes specialized in suppression of …

GARP是潜伏转化生长因子β（TGF-β）的I型跨膜细胞表面对接受体，在调节性T淋巴细胞和血小板上大量表达。 GARP调节膜结合潜伏TGF-β的可用性并调节其活化。